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Published 29 September 2009, doi:10.1136/bmj.b3677
Cite this as: BMJ 2009;339:b3677
Ben Y Reis, assistant professor1,2, Isaac S Kohane, professor1,2, Kenneth D Mandl, associate professor1,2
1 Childrens Hospital Informatics Program at the Harvard-MIT Division of Health Sciences and Technology, Childrens Hospital Boston, Boston, MA, USA, 2 Harvard Medical School, Boston, MA
Correspondence to: B Y Reis, 1 Autumn St, Room 540.1, Boston, MA 02115 Ben_Reis{at}harvard.edu
Design Bayesian models, known as intelligent histories, used to predict a patients risk of receiving a future diagnosis of abuse, based on the patients diagnostic history. Retrospective evaluation of the models predictions using an independent testing set.
Setting A state-wide claims database covering six years of inpatient admissions to hospital, admissions for observation, and encounters in emergency departments.
Population All patients aged over 18 who had at least four years between their earliest and latest visits recorded in the database (561 216 patients).
Main outcome measures Timeliness of detection, sensitivity, specificity, positive predictive values, and area under the ROC curve.
Results 1.04% (5829) of the patients met the narrow case definition for abuse, while 3.44% (19 303) met the broader case definition for abuse. The model achieved sensitive, specific (area under the ROC curve of 0.88), and early (10-30 months in advance, on average) prediction of patients future risk of receiving a diagnosis of abuse. Analysis of model parameters showed important differences between sexes in the risks associated with certain diagnoses.
Conclusions Commonly available longitudinal diagnostic data can be useful for predicting a patients future risk of receiving a diagnosis of abuse. This modelling approach could serve as the basis for an early warning system to help doctors identify high risk patients for further screening.
This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. See: http://creativecommons.org/licenses/by-nc/2.0/ and http://creativecommons.org/licenses/by-nc/2.0/legalcode.
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