Published 14 July 2009, doi:10.1136/bmj.b2576
Cite this as: BMJ 2009;339:b2576

Research

Laparoscopic fundoplication compared with medical management for gastro-oesophageal reflux disease: cost effectiveness study

¹ Centre for Health Economics, University of York, Heslington, York YO1 5DD, ² Faculty of Economics and Business Sciences, Campus Universitario de la Cartuja, 18071 Granada, Spain

Objective To describe the long term costs, health benefits, and cost effectiveness of laparoscopic surgery compared with those of continued medical management for patients with gastro-oesophageal reflux disease (GORD).

Design We estimated resource use and costs for the first year on the basis of data from the REFLUX trial. A Markov model was used to extrapolate cost and health benefit over a lifetime using data collected in the REFLUX trial and other sources.

Participants The model compared laparoscopic surgery and continued proton pump inhibitors in male patients aged 45 and stable on GORD medication.

Intervention Laparoscopic surgery versus continued medical management.

Main outcome measures We estimated quality adjusted life years and GORD related costs to the health service over a lifetime. Sensitivity analyses considered other plausible scenarios, in particular size and duration of treatment effect and the GORD symptoms of patients in whom surgery is unsuccessful.

Main results The base case model indicated that surgery is likely to be considered cost effective on average with an incremental cost effectiveness ratio of £2648 (3110; US$4385) per quality adjusted life year and that the probability that surgery is cost effective is 0.94 at a threshold incremental cost effectiveness ratio of £20 000. The results were sensitive to some assumptions within the extrapolation modelling.

Conclusion Surgery seems to be more cost effective on average than medical management in many of the scenarios examined in this study. Surgery might not be cost effective if the treatment effect does not persist over the long term, if patients who return to medical management have poor health related quality of life, or if proton pump inhibitors were cheaper. Further follow-up of patients from the REFLUX trial may be valuable.

Trial registration ISRCTN15517081 [controlled-trials.com] .

© Epstein et al 2009
This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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This article has been cited by other articles:

• Ford, A. C, Moayyedi, P. (2009). Treatment of chronic gastro-oesophageal reflux disease. BMJ 339: b2481-b2481 [Full text]  

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