Published 24 November 2008, doi:10.1136/bmj.a2245
Cite this as: BMJ 2008;337:a2245

Research

Drug use in children: cohort study in three European countries

¹ Department of Medical Informatics, Erasmus University Medical Centre, 3000CA Rotterdam, Netherlands, ² Department of Epidemiology, Erasmus University Medical Centre, Rotterdam, Netherlands, ³ Department of Epidemiology and Medical Informatics, Institute of Biomedical Technologies, National Research Council, 20090 Segrate, Milan, Italy, ⁴ GH Sergievsky Center, School of Public Health, Columbia University, New York, NY 10032, US, ⁵ Centre for Paediatric Pharmacy Research, School of Pharmacy and Institute of Child Health, University of London, London WC1N 1AX, ⁶ International Pharmacoepidemiology and Pharmacoeconomics Research Centre, 20033 Desio, Italy, ⁷ Department of Paediatrics, University Hospital, Padua, Italy, ⁸ Società Servizi Telematici 35138 Padua, Italy, ⁹ Consorzio per Valutazioni Biologiche e Farmacologiche, 27100 Pavia, Italy

Objective To provide an overview of drug use in children in three European countries.

Design Retrospective cohort study, 2000-5.

Setting Primary care research databases in the Netherlands (IPCI), United Kingdom (IMS-DA), and Italy (Pedianet).

Participants 675 868 children aged up to 14 (Italy) or 18 (UK and Netherlands).

Main outcome measure Prevalence of use per year calculated by drug class (anatomical and therapeutic). Prevalence of "recurrent/chronic" use (three or more prescriptions a year) and "non-recurrent" or "acute" use (less than three prescriptions a year) within each therapeutic class. Descriptions of the top five most commonly used drugs evaluated for off label status within each anatomical class.

Results Three levels of drug use could be distinguished in the study population: high (>10/100 children per year), moderate (1-10/100 children per year), and low (<1/100 children per year). For all age categories, anti-infective, dermatological, and respiratory drugs were in the high use group, whereas cardiovascular and antineoplastic drugs were always in the low use group. Emollients, topical steroids, and asthma drugs had the highest prevalence of recurrent use, but relative use of low prevalence drugs was more often recurrent than acute. In the top five highest prevalence drugs topical inhaled and systemic steroids, oral contraceptives, and topical or systemic antifungal drugs were most commonly used off label.

Conclusion This overview of outpatient paediatric prescription patterns in a large European population could provide information to prioritise paediatric therapeutic research needs.

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