Published 3 July 2008, doi:10.1136/bmj.a120
Cite this as: BMJ 2008;337:a120

Research

Imported malaria and high risk groups: observational study using UK surveillance data 1987-2006

Adrian D Smith, specialist registrar in public health1, David J Bradley, emeritus professor of tropical hygiene1,2, Valerie Smith, malaria travel adviser1, Marie Blaze, malaria travel adviser1, Ron H Behrens, senior lecturer2, Peter L Chiodini, director, Malaria Reference Laboratory1,2, Christopher J M Whitty, professor of international health1,2

1 HPA Malaria Reference Laboratory, London School of Hygiene and Tropical Medicine, London WC1E 6AU, 2 Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine

Correspondence: A Smith, Division of Public Health and Primary Care, University of Oxford, Oxford OX3 7LF adrian.smith{at}dphpc.ox.ac.uk

Objective To examine temporal, geographic, and sociodemographic trends in case reporting and case fatality of malaria in the United Kingdom.

Setting National malaria reference laboratory surveillance data in the UK.

Design Observational study using prospectively gathered surveillance data and data on destinations from the international passenger survey.

Participants 39 300 cases of proved malaria in the UK between 1987 and 2006.

Main outcome measures Plasmodium species; sociodemographic details (including age, sex, and country of birth and residence); mortality; destination, duration, and purpose of international travel; and use of chemoprophylaxis.

Results Reported cases of imported malaria increased significantly over the 20 years of the study; an increasing proportion was attributable to Plasmodium falciparum (P falciparum/P vivax reporting ratio 1.3:1 in 1987-91 and 5.4:1 in 2002-6). P vivax reports declined from 3954 in 1987-91 to 1244 in 2002-6. Case fatality of reported P falciparum malaria did not change over this period (7.4 deaths per 1000 reported cases). Travellers visiting friends and relatives, usually in a country in Africa or Asia from which members of their family migrated, accounted for 13 215/20 488 (64.5%) of all malaria reported, and reports were geographically concentrated in areas where migrants from Africa and South Asia to the UK have settled. People travelling for this purpose were at significantly higher risk of malaria than other travellers and were less likely to report the use of any chemoprophylaxis (odds ratio of reported chemoprophylaxis use 0.23, 95% confidence interval 0.21 to 0.25).

Conclusions Despite the availability of highly effective preventive measures, the preventable burden from falciparum malaria has steadily increased in the UK while vivax malaria has decreased. Provision of targeted and appropriately delivered preventive messages and services for travellers from migrant families visiting friends and relatives should be a priority.


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