Published 15 December 2008, doi:10.1136/bmj.a2494
Cite this as: BMJ 2008;337:a2494

Research

Risk of Parkinson’s disease after hospital contact for head injury: population based case-control study

Kathrine Rugbjerg, research fellow1, Beate Ritz, professor2, Lise Korbo, chief3, Nick Martinussen, data manager1, Jørgen H Olsen, director1

1 Institute of Cancer Epidemiology, Danish Cancer Society, 49 Strandboulevarden, DK-2100 Copenhagen, Denmark, 2 Department of Epidemiology and Environmental Health Sciences, School of Public Health, University of California at Los Angeles (UCLA), USA, 3 Department of Neurology, Bispebjerg Hospital, Copenhagen

Correspondence to: K Rugbjerg rugbjerg{at}cancer.dk

Objective To determine whether a hospital contact for a head injury increases the risk of subsequently developing Parkinson’s disease.

Design Population based case-control study.

Setting Denmark.

Participants 13 695 patients with a primary diagnosis of Parkinson’s disease in the Danish national hospital register during 1986-2006, each matched on age and sex to five population controls selected at random from inhabitants in Denmark alive at the date of the patient’s diagnosis (n=68 445).

Main outcome measures Hospital contacts for head injuries ascertained from hospital register; frequency of history of head injury.

Results An overall 50% increase in prevalence of hospital contacts for head injury was seen before the first registration of Parkinson’s disease in this population (odds ratio 1.5, 95% confidence interval 1.4 to 1.7). The observed association was, however, due almost entirely to injuries that occurred during the three months before the first record of Parkinson’s disease (odds ratio 8.0, 5.6 to 11.6), and no association was found between the two events when they occurred 10 or more years apart (1.1, 0.9 to 1.3).

Conclusions The steeply increased frequency of hospital contacts for a head injury during the months preceding the date at which Parkinson’s disease was first recorded is a consequence of the evolving movement disorder rather than its cause.


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This article has been cited by other articles:

  • Rugbjerg, K., Friis, S., Ritz, B., Schernhammer, E. S., Korbo, L., Olsen, J. H. (2009). Autoimmune disease and risk for Parkinson disease: A population-based case-control study. Neurology 73: 1462-1468 [Abstract] [Full text]  
  • (2009). Prior Head Injury and Risk for Parkinson Disease. JWatch General 2009: 6-6 [Full text]  
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