BMJ  2007;334:409 (24 February), doi:10.1136/bmj.39062.520648.BE (published 26 January 2007)

Research

Effect of reducing caffeine intake on birth weight and length of gestation: randomised controlled trial

¹ Institute of Public Health, Department of Epidemiology, University of Aarhus, 8000 Aarhus, Denmark, ² Perinatal Epidemiology Research Unit, Aarhus University Hospital, Skejby, Denmark, ³ Department of Epidemiology, University of California, Los Angeles, USA

Objective To estimate the effect of reducing caffeine intake during pregnancy on birth weight and length of gestation.

Design Randomised double blind controlled trial.

Setting Denmark.

Participants 1207 pregnant women drinking at least three cups of coffee a day, recruited before 20 weeks' gestation.

Interventions Caffeinated instant coffee (568 women) or decaffeinated instant coffee (629 women).

Main outcome measures Birth weight and length of gestation.

Results Data on birth weight were obtained for 1150 liveborn singletons and on length of gestation for 1153 liveborn singletons. No significant differences were found for mean birth weight or mean length of gestation between women in the decaffeinated coffee group (whose mean caffeine intake was 182 mg lower than that of the other group) and women in the caffeinated coffee group. After adjustment for length of gestation, parity, prepregnancy body mass index, and smoking at entry to the study the mean birth weight of babies born to women in the decaffeinated group was 16 g (95% confidence interval –40 to 73) higher than those born to women in the caffeinated group. The adjusted difference (decaffeinated group–caffeinated group) of length of gestation was –1.31 days (–2.87 to 0.25).

Conclusion A moderate reduction in caffeine intake in the second half of pregnancy has no effect on birth weight or length of gestation.

Trial registration Clinical Trials NCT00131690 [ClinicalTrials.gov] .

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Relevant Article

Subgroup analyses: how to avoid being misled

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BMJ 2007 335: 96-97. [Extract] [Full Text] [PDF]

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Randomisation method

David J Torgerson, et al.
bmj.com, 26 Feb 2007 [Full text]