BMJ  2005;331:73 (9 July), doi:10.1136/bmj.331.7508.73

Paper

Value of routine funduscopy in patients with hypertension: systematic review

¹ Department of Internal Medicine, Academic Medical Centre, PO 22660, 1100 DD Amsterdam, Netherlands, ² Department of Ophthalmology, Academic Medical Centre, Amsterdam

Objective To evaluate the additional value of funduscopy in the routine management of patients with hypertension.

Design Systematic review.

Participants Adults aged 19 or more with hypertensive retinopathy.

Data sources Medline, Embase, and the Cochrane Library from 1990.

Review methods Studies were included that assessed hypertensive retinopathy with blinding for blood pressure and cardiovascular risk factors. Studies on observer agreement had to be assessed by two or more observers and expressed as a statistic. Studies on the association between hypertensive retinopathy and hypertensive organ damage were carried out in patients with hypertension. The association between hypertensive retinopathy and cardiovascular risk was carried out in unselected normotensive and hypertensive people without diabetes mellitus.

Results The assessment of microvascular changes in the retina is limited by large variation between observers. The positive and negative predictive values for the association between hypertensive retinopathy and blood pressure were low (47% to 72% and 32% to 67%, respectively). Associations between retinal microvascular changes and cardiovascular risk were inconsistent, except for retinopathy and stroke. The increased risk of stroke, however, was also present in normotensive people with retinopathy. These studies did not adjust for other indicators of hypertensive organ damage.

Conclusion Evidence is lacking that routine funduscopy is of additional value in the management of hypertensive patients.

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