Risk of ischaemic stroke in people with migraine: systematic review and meta-analysis of observational studies

doi:10.1136/bmj.38302.504063.8F

BMJ 2005;330:63 (8 January), doi:10.1136/bmj.38302.504063.8F (published 13 December 2004)

Paper

Risk of ischaemic stroke in people with migraine: systematic review and meta-analysis of observational studies

Mahyar Etminan, pharmacoepidemiologist¹, Bahi Takkouche, professor², Francisco Caamaño Isorna, associate professor², Ali Samii, neurologist and associate professor³

¹ Divisions of Epidemiology, Royal Victoria and Vancouver Hospitals, Canada, ² Department of Preventive Medicine, University of Santiago de Compostela, Spain, ³ Department of Neurology, University of Washington, Seattle, WA 98195, USA

Correspondence to: M Etminan, Division of Clinical Epidemiology, Royal Victoria Hospital, Montreal, QC, Canada H3A 1A1 Mahyar.etminan{at}mail.mcgill.ca

Objective To explore the association between migraine and riskof ischaemic stroke.

Design Systematic review and meta-analysis.

Data sources Observational studies published between 1966 andJune 2004 (identified through Medline and Embase) that examinedthe association between migraine and risk of ischaemic stroke.

Results 14 studies (11 case-control studies and 3 cohort studies)were identified. These studies suggest that the risk of strokeis increased in people with migraine (relative risk 2.16, 95%confidence interval 1.89 to 2.48). This increase in risk wasconsistent in people who had migraine with aura (relative risk2.27, 1.61 to 3.19) and migraine without aura (relative risk1.83, 1.06 to 3.15), as well as in those taking oral contraceptives(relative risk 8.72, 5.05 to 15.05).

Conclusions Data from observational studies suggest that migrainemay be a risk factor in developing stroke. More studies areneeded to explore the mechanism of this potential association.In addition, the risk of migraine among users of oral contraceptivesmust be further investigated.

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Migraine may be a risk factor for stroke
BMJ 2005 330: 0. [Full Text]

Migraine and ischaemic stroke: D J Thomas
BMJ 2005 330: 54-55. [Extract] [Full Text] [PDF]

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