BMJ  2004;329:941 (23 October), doi:10.1136/bmj.38258.507928.55 (published 6 October 2004)

Paper

Childhood predictors of self reported chronic fatigue syndrome/myalgic encephalomyelitis in adults: national birth cohort study

Russell Viner, honorary senior lecturer in adolescent medicine1, Matthew Hotopf, professor of general hospital psychiatry2

1 Department of Paediatrics, Royal Free and University College Medical School, Middlesex Hospital, London W1T 3AA, 2 Department of Psychological Medicine, Institute of Psychiatry, London SE5 8AF

Correspondence to: R Viner R.Viner{at}ich.ucl.ac.uk

Objective To study childhood risk factors for chronic fatigue syndrome in adult life.

Design Examination of data from the 1970 British birth cohort.

Participants 16 567 babies born 5-11 April 1970, followed up at 5, 10, 16, and 29-30 years.

Main outcome measures Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) identified by self report at age 30 years. Data from childhood from questionnaires given to parents and teachers. Maternal mental health assessed with the malaise inventory.

Results 93 (0.8%, 95% confidence interval 0.7 to 1.0) of 11 261 participants reported ever having CFS/ME, and 48 (0.4%, 0.3 to 0.6) had the condition currently. Higher risk of CFS/ME was associated with having a limiting longstanding condition in childhood (odds ratio 2.3, 1.4 to 3.9), female sex (2.3, 1.4 to 2.6), and high social class in childhood (2.2, 1.4 to 3.5). Higher levels of exercise in childhood were associated with lower risk (0.5, 0.2 to 0.9). Maternal psychological disorder, psychological problems in childhood, birth weight, birth order, atopy, obesity, school absence, academic ability, and parental illness were not associated with risk of CFS/ME.

Conclusions We identified no association between maternal or child psychological distress, academic ability, parental illness, atopy, or birth order and increasing risk of lifetime CFS/ME. Sedentary behaviour increased the risk.


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Rapid Responses:

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Relating to activity levels in childhood and ME
Jeanne M Davey
bmj.com, 6 Oct 2004 [Full text]
Advice to exercise more only likely to help a small percentage at most
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