BMJ 2000;321:1179-1183 ( 11 November )

Papers

Assessment of a genetic contribution to osteoarthritis of the hip: sibling study

Peter Lanyon, consultant rheumatologist, ^a Kenneth Muir, senior lecturer, ^b Sally Doherty, senior research metrologist, ^c Michael Doherty, professor. ^c

^a Clinical Immunology Unit, Queens Medical Centre, Nottingham NG7 2UH, ^b Department of Epidemiology and Public Health Medicine, Queens Medical Centre, ^c Academic Rheumatology, City Hospital, Nottingham NG5 1PB

Correspondence to: P Lanyon

Objectives: To study the influence of genetics on the development of hip osteoarthritis as determined by structural change on plain radiographs.
Design: Sibling study.
Setting: Nottinghamshire, England.
Participants: 392 index participants with hip osteoarthritis of sufficient severity to warrant total hip replacement, 604 siblings of the index participants, and 1718 participants who had undergone intravenous urography.
Main outcome measure: Odds ratios for hip osteoarthritis in siblings.
Results: The age adjusted odds ratios in siblings were 4.9 (95% confidence interval, 3.9 to 6.4) for probable hip osteoarthritis and 6.4 (4.5 to 9.1) for definite hip osteoarthritis. These values were not significantly altered by adjusting for other risk factors.
Conclusion: Siblings have a high risk of hip osteoarthritis as shown by structural changes on plain radiographs. One explanation is that hip osteoarthritis is under strong genetic influence.

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Genetic Link to Hip Osteoarthritis

Iain Chambers
bmj.com, 22 Nov 2000 [Full text]

Assessment of a genetic contribution to osteoarthritis of the hip

John Lourie
bmj.com, 8 Dec 2000 [Full text]

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