Fetal and maternal contributions to risk of pre-eclampsia: population based study

BMJ 1998;316:1343-1347 ( 2 May )

Papers

Fetal and maternal contributions to risk of pre-eclampsia: population based study

Rolv Terje Lie, professor, ^a Svein Rasmussen, obstetrician, ^b Helge Brunborg, researcher, ^c Håkon K Gjessing, researcher, ^a Erik Lie-Nielsen, managing director, ^b Lorentz M Irgens, professor. ^b

^a Division for Medical Statistics, University of Bergen, Armauer Hansen's Building, Haukeland Hospital, 5021 Bergen, Norway, ^b Medical Birth Registry of Norway, Armauer Hansen's Building, Haukeland Hospital, 5021 Bergen, ^c Statistics Norway, PO Box 8131 Dep, 0033 Oslo, Norway

Correspondence to: Professor Lie rolv.lie{at}smis.uib.no

Objective: To use familial patterns of recurrence of pre-eclampsia to investigate whether paternal genes expressedin the fetus contribute to the mother's risk of pre-eclampsiaand whether mother's susceptibility to pre-eclampsia is relatedto maternal inheritance by mitochondrial DNA.
Design: Linked data on pregnancies of different women who had children with the same father, and subsequently linkeddata on pregnancies of half sisters who either had same motherand different fathers or had same father and different mothers.
Setting: Population based data from the Medical Birth Registry of Norway covering all births since 1967 (about 1.7million) and the Norwegian Central Population Register.
Main outcome measures: Relative risk of pre-eclampsia after a previous pre-eclamptic pregnancy in the family. Relativerisks approximated by odds ratios.
Results: If a woman becomes pregnant by a man who has already fathered a pre-eclamptic pregnancy in a different womanher risk of developing pre-eclampsia is 1.8 (95% confidence interval1.2 to 2.6). If the woman has a half sister who had pre-eclampsiaand with whom she shares the same mother but different fathersthe risk of pre-eclampsia is 1.6 (0.9 to2.6). If the two sistershave the same father but different mothers the risk is 1.8 (1.01to 2.9).
Conclusions: Both the mother and the fetus contribute to the risk of pre-eclampsia, the contribution of the fetus beingaffected by paternal genes. Mitochondrial genes, which are transmittedby mothers, do not seem to contribute to the risk.

Key messages

Paternal genes in the fetus may contribute substantially to a pregnant woman's risk of pre-eclampsia
The role of the fetus may be as important as that of the mother
Purely maternal inheritance (specifically by mitochondrial DNA) is probably not involved in pre-eclampsia
Search for specific genes that predispose for pre-eclampsia should include the fetus as well as the mother

© BMJ 1998

CiteULike

Complore

Connotea

Del.icio.us Add to Digg

Digg

Technorati What's this?

Relevant Articles

Recurrence of pre-eclampsia across generations: exploring fetal and maternal genetic components in a population based cohort: Rolv Skjærven, Lars J Vatten, Allen J Wilcox, Thorbjørn Rønning, Lorentz M Irgens, and Rolv Terje Lie
BMJ 2005 331: 877. [Abstract] [Full Text] [PDF]

The subtleties of medicine
BMJ 1998 316: 0. [Full Text]

Father's genes influence risk of pre-eclampsia
BMJ 1998 316: 0. [Full Text]

This article has been cited by other articles:

Mikolajczyk, R. T., Zhang, J., Ford, J., Grewal, J. (2008). Effects of Interpregnancy Interval on Blood Pressure in Consecutive Pregnancies. Am J Epidemiol 168: 422-426 [Abstract] [Full text]
Barton, J. R., Sibai, B. M. (2008). Prediction and Prevention of Recurrent Preeclampsia. Obstet Gynecol 112: 359-372 [Abstract] [Full text]
Tollanes, M. C, Rasmussen, S., Irgens, L. M (2008). Caesarean section among relatives. Int J Epidemiol 0: dyn100v1-dyn100 [Abstract] [Full text]
Tan, C. Y., Ho, J. F.V., Chong, Y. S., Loganath, A., Chan, Y. H., Ravichandran, J., Lee, C. G., Chong, S. S. (2008). Paternal contribution of HLA-G*0106 significantly increases risk for pre-eclampsia in multigravid pregnancies. Mol Hum Reprod 14: 317-324 [Abstract] [Full text]
Hiby, S.E., Regan, L., Lo, W., Farrell, L., Carrington, M., Moffett, A. (2008). Association of maternal killer-cell immunoglobulin-like receptors and parental HLA-C genotypes with recurrent miscarriage. Hum Reprod 23: 972-976 [Abstract] [Full text]
Rasmussen, S., Irgens, L. M. (2008). History of Fetal Growth Restriction Is More Strongly Associated With Severe Rather Than Milder Pregnancy-Induced Hypertension. Hypertension 51: 1231-1238 [Abstract] [Full text]
Wilcox, A. J., Skjaerven, R., Lie, R. T. (2008). Familial Patterns of Preterm Delivery: Maternal and Fetal Contributions. Am J Epidemiol 167: 474-479 [Abstract] [Full text]
Gjessing, H. K., Lie, R. T. (2008). Biometrical modelling in genetics: are complex traits too complex?. Stat Methods Med Res 17: 75-96 [Abstract]
Getahun, D., Ananth, C. V., Oyelese, Y., Chavez, M. R., Kirby, R. S., Smulian, J. C. (2007). Primary Preeclampsia in the Second Pregnancy: Effects of Changes in Prepregnancy Body Mass Index Between Pregnancies. Obstet Gynecol 110: 1319-1325 [Abstract] [Full text]
Catov, J. M, Ness, R. B, Kip, K. E, Olsen, J. (2007). Risk of early or severe preeclampsia related to pre-existing conditions. Int J Epidemiol 36: 412-419 [Abstract] [Full text]
Rasmussen, S., Irgens, L. M. (2007). Pregnancy-Induced Hypertension in Women Who Were Born Small. Hypertension 49: 806-812 [Abstract] [Full text]
Johnson, M.P., Fitzpatrick, E., Dyer, T.D., Jowett, J.B.M., Brennecke, S.P., Blangero, J., Moses, E.K. (2007). Identification of two novel quantitative trait loci for pre-eclampsia susceptibility on chromosomes 5q and 13q using a variance components-based linkage approach. Mol Hum Reprod 13: 61-67 [Abstract] [Full text]
Moses, E.K., Fitzpatrick, E., Freed, K.A., Dyer, T.D., Forrest, S., Elliott, K., Johnson, M.P., Blangero, J., Brennecke, S.P. (2006). Objective prioritization of positional candidate genes at a quantitative trait locus for pre-eclampsia on 2q22. Mol Hum Reprod 12: 505-512 [Abstract] [Full text]
Lie, R. T., Wilcox, A. J., Skjaerven, R. (2006). Maternal and Paternal Influences on Length of Pregnancy.. Obstet Gynecol 107: 880-885 [Abstract] [Full text]
Hansson, S.R., Chen, Y., Brodszki, J., Chen, M., Hernandez-Andrade, E., Inman, J.M., Kozhich, O.A., Larsson, I., Marsal, K., Medstrand, P., Xiang, C.C., Brownstein, M.J. (2006). Gene expression profiling of human placentas from preeclamptic and normotensive pregnancies. Mol Hum Reprod 12: 169-179 [Abstract] [Full text]
Skjaerven, R., Vatten, L. J, Wilcox, A. J, Ronning, T., Irgens, L. M, Lie, R. T. (2005). Recurrence of pre-eclampsia across generations: exploring fetal and maternal genetic components in a population based cohort. BMJ 331: 877- [Abstract] [Full text]
Getahun, D., Ananth, C. V., Selvam, N., Demissie, K. (2005). Adverse Perinatal Outcomes Among Interracial Couples in the United States. Obstet Gynecol 106: 81-88 [Abstract] [Full text]
Caughey, A. B., Stotland, N. E., Washington, A. E., Escobar, G. J. (2005). Maternal Ethnicity, Paternal Ethnicity, and Parental Ethnic Discordance: Predictors of Preeclampsia. Obstet Gynecol 106: 156-161 [Abstract] [Full text]
Freed, K.A., Cooper, D.W., Brennecke, S.P., Moses, E.K. (2005). Detection of CAG repeats in pre-eclampsia/eclampsia using the repeat expansion detection method. Mol Hum Reprod 11: 481-487 [Abstract] [Full text]
Hiby, S. E., Walker, J. J., O'Shaughnessy, K. M., Redman, C. W.G., Carrington, M., Trowsdale, J., Moffett, A. (2004). Combinations of Maternal KIR and Fetal HLA-C Genes Influence the Risk of Preeclampsia and Reproductive Success. J. Exp. Med. 200: 957-965 [Abstract] [Full text]
Saftlas, A. F., Logsden-Sackett, N., Wang, W., Woolson, R., Bracken, M. B. (2004). Work, Leisure-Time Physical Activity, and Risk of Preeclampsia and Gestational Hypertension. Am J Epidemiol 160: 758-765 [Abstract] [Full text]
Li, D.-K., Odouli, R., Liu, L., Vinson, M., Trachtenberg, E. (2004). Transmission of Parentally Shared Human Leukocyte Antigen Alleles and the Risk of Preterm Delivery. Obstet Gynecol 104: 594-600 [Abstract] [Full text]
Taylor, A. (2004). Pre-eclampsia and the risk of cancer. BMJ 328: 909-910 [Full text]
Hylenius, S., Nybo Andersen, A.-M., Melbye, M., Hviid, T. V. F. (2004). Association between HLA-G genotype and risk of pre-eclampsia: a case-control study using family triads. Mol Hum Reprod 10: 237-246 [Abstract] [Full text]
Vatten, L. J, Skjaerven, R. (2003). Effects on pregnancy outcome of changing partner between first two births: prospective population study. BMJ 327: 1138- [Abstract] [Full text]
Saftlas, A. F., Levine, R. J., Klebanoff, M. A., Martz, K. L., Ewell, M. G., Morris, C. D., Sibai, B. M. (2003). Abortion, Changed Paternity, and Risk of Preeclampsia in Nulliparous Women. Am J Epidemiol 157: 1108-1114 [Abstract] [Full text]
Basso, O., Weinberg, C. R., Baird, D. D., Wilcox, A. J., Olsen, J. (2003). Subfecundity as a Correlate of Preeclampsia: A Study within the Danish National Birth Cohort. Am J Epidemiol 157: 195-202 [Abstract] [Full text]
Skomsvoll, J. F., Baste, V., Irgens, L. M., Ostensen, M. (2002). The Recurrence Risk of Adverse Outcome in the Second Pregnancy in Women With Rheumatic Disease. Obstet Gynecol 100: 1196-1202 [Abstract] [Full text]
Reimer, T., Koczan, D., Gerber, B., Richter, D., Thiesen, H.J., Friese, K. (2002). Microarray analysis of differentially expressed genes in placental tissue of pre-eclampsia: up-regulation of obesity-related genes. Mol Hum Reprod 8: 674-680 [Abstract] [Full text]
Dawson, L. M., Parfrey, P. S., Hefferton, D., Dicks, E. L., Cooper, M. J., Young, D., Marsden, P. A. (2002). Familial Risk of Preeclampsia in Newfoundland: A Population-Based Study. J. Am. Soc. Nephrol. 13: 1901-1906 [Abstract] [Full text]
Skjaerven, R., Wilcox, A. J., Lie, R. T. (2002). The Interval between Pregnancies and the Risk of Preeclampsia. NEJM 346: 33-38 [Abstract] [Full text]
Vatten, L. J., Odegard, R. A., Nilsen, S. T., Salvesen, K. A., Austgulen, R. (2002). Relationship of Insulin-Like Growth Factor-I and Insulin-Like Growth Factor Binding Proteins in Umbilical Cord Plasma to Preeclampsia and Infant Birth Weight. Obstet Gynecol 99: 85-90 [Abstract] [Full text]
Zusterzeel, P L M, Morsche, R t., Raijmakers, M T M, Roes, E M, Peters, W H M, Steegers, E A P (2002). Paternal contribution to the risk for pre-eclampsia. J. Med. Genet. 39: 44-45 [Full text]
Trogstad, L. I., Eskild, A., Magnus, P., Samuelsen, S. O., Nesheim, B.-I. (2001). Changing paternity and time since last pregnancy; the impact on pre-eclampsia risk. A study of 547 238 women with and without previous pre-eclampsia. Int J Epidemiol 30: 1317-1322 [Abstract] [Full text]
Eskenazi, B., Harley, K. (2001). Commentary: Revisiting the primipaternity theory of pre-eclampsia. Int J Epidemiol 30: 1323-1324 [Full text]
Irgens, H. U, Reisater, L., Irgens, L. M, Lie, R. T, Roberts, J. M (2001). Long term mortality of mothers and fathers after pre-eclampsia: population based cohort study Pre-eclampsia and cardiovascular disease later in life: who is at risk?. BMJ 323: 1213-1217 [Abstract] [Full text]
Odegard, R. A., Vatten, L. J., Nilsen, S. T., Salvesen, K. A., Vefring, H., Austgulen, R. (2001). Umbilical Cord Plasma Interleukin-6 and Fetal Growth Restriction in Preeclampsia: A Prospective Study in Norway. Obstet Gynecol 98: 289-294 [Abstract] [Full text]
Conde-Agudelo, A., Heyborne, K., Fausett, M. B., Esplin, M. S., Varner, M. W. (2001). Paternal and Maternal Components of the Predisposition to Preeclampsia. NEJM 345: 149-150 [Full text]
Esplin, M. S., Fausett, M. B., Fraser, A., Kerber, R., Mineau, G., Carrillo, J., Varner, M. W. (2001). Paternal and Maternal Components of the Predisposition to Preeclampsia. NEJM 344: 867-872 [Abstract] [Full text]
Pipkin, F. B. (2001). Risk Factors for Preeclampsia. NEJM 344: 925-926 [Full text]
ODEGARD, R. A., VATTEN, L. J., NILSEN, S. T., SALVESEN, K. A., AUSTGULEN, R. (2000). Preeclampsia and Fetal Growth. Obstet Gynecol 96: 950-955 [Abstract] [Full text]
RASMUSSEN, S., IRGENS, L. M., ALBRECHTSEN, S., DALAKER, K. (2000). Predicting Preeclampsia in the Second Pregnancy from Low Birth Weight in the First Pregnancy. Obstet Gynecol 96: 696-700 [Abstract] [Full text]
Salha, O., Sharma, V., Dada, T., Nugent, D., Rutherford, A.J., Tomlinson, A.J., Philips, S., Allgar, V., Walker, J.J. (1999). The influence of donated gametes on the incidence of hypertensive disorders of pregnancy. Hum Reprod 14: 2268-2273 [Abstract] [Full text]
(1998). Risk of Preeclampsia Related to Paternal Genes. JWatch Women's Health 1998: 9-9 [Full text]