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Relation of infant diet to childhood health: seven year follow up of cohort of children in Dundee infant feeding study

^a Departments of Child Health, Epidemiology and Public Health, and Obstetrics and Gynaecology, Ninewells Hospital and Medical School, Dundee DD1 9SY

Correspondence to: Dr Forsyth stewart.f@dth.scot.nhs.uk

Objective: To investigate the relation of infant feeding practice to childhood respiratory illness, growth, body composition, and blood pressure.
Design: Follow up study of a cohort of children (mean age 7.3 years) who had detailed infant feeding and demographic data collected prospectively during the first two years of life.
Setting: Dundee.
Subjects: 674 infants, of whom 545 (81%) were available for study. Data on respiratory illness were available for 545 children (mean age 7.3 (range 6.1- 9.9) years); height for 410 children; weight and body mass index for 412 children; body composition for 405 children; blood pressure for 301 children (mean age 7.2 (range 6.9-10.0) years).
Main outcome measures: Respiratory illness, weight, height, body mass index, percentage body fat, and blood pressure in relation to duration of breast feeding and timing of introduction of solids.
Results: After adjustment for the significant confounding variables the estimated probability of ever having respiratory illness in children who received breast milk exclusively for at least 15 weeks was consistently lower (17.0% (95% confidence interval 15.9% to 18.1%) for exclusive breast feeding, 31.0% (26.8% to 35.2%) for partial breast feeding, and 32.2% (30.7% to 33.7%) for bottle feeding. Solid feeding before 15 weeks was associated with an increased probability of wheeze during childhood (21.0% (19.9% to 22.1%) v 9.7% (8.6% to 10.8%)). It was also associated with increased percentage body fat and weight in childhood (mean body fat 18.5% (18.2% to 18.8%) v 16.5% (16.0% to 17.0%); weight standard deviation score 0.02 (-0.02 to 0.06) v -0.09 (-0.16 to 0.02). Systolic blood pressure was raised significantly in children who were exclusively bottle fed compared with children who received breast milk (mean 94.2 (93.5 to 94.9) mm Hg v 90.7 (89.9 to 91.7) mm Hg).
Conclusions: The probability of respiratory illness occurring at any time during childhood is significantly reduced if the child is fed exclusively breast milk for 15 weeks and no solid foods are introduced during this time. Breast feeding and the late introduction of solids may have a beneficial effect on childhood health and subsequent adult disease.

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• MacDonald, A (2003). Is breast best? Is early solid feeding harmful?. The Journal of the Royal Society for the Promotion of Health 123: 169-174 [Abstract]  
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• Norman, M., Martin, H. (2003). Preterm Birth Attenuates Association Between Low Birth Weight and Endothelial Dysfunction. Circulation 108: 996-1001 [Abstract] [Full text]  
• Oddy, W. H., Peat, J. K. (2003). Breastfeeding, Asthma, and Atopic Disease: An Epidemiological Review of the Literature. J Hum Lact 19: 250-261 [Abstract]  
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• Foote, K D, Marriott, L D (2003). Weaning of infants. Arch. Dis. Child. 88: 488-492 [Abstract] [Full text]  
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• Cole Johnson, C., Ownby, D. R., Zoratti, E. M., Hensley Alford, S., Williams, L. K., Joseph, C. L. M. (2002). Environmental Epidemiology of Pediatric Asthma and Allergy. Epidemiol Rev 24: 154-175 [Full text]  
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• Nicoll, A, Williams, A (2002). Breast feeding. Arch. Dis. Child. 87: 91-92 [Full text]  
• Singhal, A., Farooqi, I S., O'Rahilly, S., Cole, T. J, Fewtrell, M., Lucas, A. (2002). Early nutrition and leptin concentrations in later life. Am. J. Clin. Nutr. 75: 993-999 [Abstract] [Full text]  
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• Walker, M. (2002). Expanding Breastfeeding Promotion and Support in the Special Supplemental Nutrition Program for Women, Infants and Children (WIC). J Hum Lact 18: 115-124  
• Dell, S., To, T. (2001). Breastfeeding and Asthma in Young Children: Findings From a Population-Based Study. Arch Pediatr Adolesc Med 155: 1261-1265 [Abstract] [Full text]  
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• Martin, F. L. (2001). Genotoxins and the initiation of sporadic breast cancer. Mutagenesis 16: 155-161 [Abstract] [Full text]  
• Binns, C. W., Lee, M., Scott, J. A. (2001). The Fetal Origins of Disease Hypothesis: Public Health Implications for the Asia-Pacific Region. Asia Pac J Public Health 13: 68-73 [Abstract]  
• Aarts, C., Kylberg, E., Hornell, A., Hofvander, Y., Gebre-Medhin, M., Greiner, T. (2000). How exclusive is exclusive breastfeeding? A comparison of data since birth with current status data. Int J Epidemiol 29: 1041-1046 [Abstract] [Full text]  
• Wharton, B. (2000). Patterns of Complementary Feeding (Weaning) in Countries of the European Union: Topics for Research. Pediatrics 106: 1273-1273 [Full text]  
• de Onis, M., Blossner, M. (2000). Prevalence and trends of overweight among preschool children in developing countries. Am. J. Clin. Nutr. 72: 1032-1039 [Abstract] [Full text]  
• Shima, M., Adachi, M. (2000). Effect of outdoor and indoor nitrogen dioxide on respiratory symptoms in schoolchildren. Int J Epidemiol 29: 862-870 [Abstract] [Full text]  
• Ravelli, A C J, van der Meulen, J H P, Osmond, C, Barker, D J P, Bleker, O P (2000). Infant feeding and adult glucose tolerance, lipid profile, blood pressure, and obesity. Arch. Dis. Child. 82: 248-252 [Abstract] [Full text]  
• Oddy, W H, Holt, P G, Sly, P D, Read, A W, Landau, L I, Stanley, F J, Kendall, G E, Burton, P R (1999). Association between breast feeding and asthma in 6 year old children: findings of a prospective birth cohort study. BMJ 319: 815-819 [Abstract] [Full text]  
• Hoddinott, P., Pill, R. (1999). Qualitative study of decisions about infant feeding among women in east end of London. BMJ 318: 30-34 [Abstract] [Full text]  
• Jacobs, S., Bronner, A., Centuori, S., Cattaneo, A., Davanzo, R., Burmaz, T., Del Santo, M., Asante, M., Asante, K. (1998). Marketing of breast milk substitutes. BMJ 317: 350-350 [Full text]