Fortnightly Review: Paget's disease of bone: diagnosis and management

BMJ 1996;312:491-494 (24 February)

Education and debate

Fortnightly Review: Paget's disease of bone: diagnosis and management

David Hosking, consultant physician,^a Pierre J Meunier, professor,^b Johann D Ringe, professor,^c Jean-Yves Reginster, professor,^d Carlo Gennari, professor ^e

^a City Hospital, Hucknall Road, Nottingham NG5 1PB, ^b Service de Rhumatologie et de Pathologie Osseuse, Hopital Edouard Herriot, Lyon, France, ^c Klinikum Leverkusen, University of Cologne, Leverkusen, Germany, ^d Centre Universitaire d'Investigation du Metabolisme Osseux et du Cartilage Articulaire, Liege, Belgium, ^e Instituto de Patologia Medica, Policlinico "Le Scotto," Siena, Italy

Correspondence to: Dr Hosking.

Summary points

Paget's disease is a localised monostotic or polyostotic progressive bone disease of uncertain origin (it may be caused by a slow viral infection)
It is characterised by increased bone remodelling, leading to pain, fractures, and deformities with the risk of skeletal, articular, or neurological complications
Radiography, scintigraphy, and bone biochemistry are useful tools in achieving a positive diagnosis
The primary aim of treatment is to reduce pain and the risk of developing long term complications
Potent antiresorptive drugs are now available which control the increased bone remodelling and have led to a dramatic improvement in treatment

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Relevant Article

Disodium pamidronate has beneficial effect in Paget's disease of bone: Kuntal Chakravarty, Peter Merry, and David G I Scott
BMJ 1996 312: 1476-1477. [Extract] [Full Text]

This article has been cited by other articles:

Chakravarty, K., Merry, P., Scott, D. G I (1996). Disodium pamidronate has beneficial effect in Paget's disease of bone. BMJ 312: 1476c-1477 [Full text]