BMJ 1996;312:212-215 (27 January)

Papers

Magnitude of benefit from earlier thrombolytic treatment in acute myocardial infarction: new evidence from Grampian region early anistreplase trial (GREAT)

John Rawles, honorary senior lecturer a

a Medicines Assessment Research Unit, University of Aberdeen, Aberdeen AB9 2ZD

Abstract

Objective: To generalise from the results of the Grampian region early anistreplase trial (GREAT) and to express the benefit of earlier thrombolysis in terms of lives saved per hour of earlier treatment.
Design: Multivariate analysis of a randomised double blind trial.
Setting: 29 rural practices in Grampian region and teaching hospitals in Aberdeen.
Subjects: 311 patients with suspected acute myocardial infarction and without contraindications to thrombolysis who were seen by their general practitioners within four hours of the start of symptoms.
Interventions: Anistreplase 30 units given intravenously, either by general practitioners before hospitalisation or later in hospital.
Main outcome measure: Death within 30 months of entry into trial.
Results: Death within 30 months was positively related to age (P<0.0001) and to delay between start of symptoms and thrombolytic treatment (P=0.0004). However, the probability of dying rose exponentially with earlier presentation, so death within 30 months was negatively related to the logarithm of the time of randomisation (P=0.0163). In patients presenting two hours after start of symptoms each hour's delay in receiving thrombolysis led to the loss of 21 lives per 1000 within 30 days (95% confidence interval 1 to 94 lives per 1000) (P=0.03) and 69 lives per 1000 within 30 months (16 to 141 lives per 1000) (P=0.0004).
Conclusions: The magnitude of the benefit from earlier thrombolysis is such that giving thrombolytic treatment to patients with acute myocardial infarction should be accorded the same degree of urgency as the treatment of cardiac arrest.

Key messages

  • Key messages

  • However, studies comparing treatment in the community with later treatment in hospital showed that earlier treatment did not significantly reduce mortality in the following month

  • Continued follow up of Grampian region early anistreplase trial showed that mortality benefit of prehospital thrombolysis trebled between 30 days and 30 months after entry into trial

  • Patients who sought medical help quickly after start of symptoms had more severe infarction, and thus a higher mortality risk, than those seeking help later, which can mask greater efficacy of earlier thrombolysis

  • Giving thrombolytic treatment at the first opportunity should be considered as urgent as treatment of cardiac arrest


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