Papers

Increased familial risk and evidence of genetic factor in migraine

^a Department of Neurology, Glostrup Hospital, University of Copenhagen, DK-2600 Glostrup, Denmark

Correspondence to: Dr Russell.

Abstract

Objective: To investigate familial occurrence of migraine with and without aura.
Design: Familial occurrence of migraine with and without aura among first degree relatives and spouses of probands with migraine with or without aura and those who had never had migraine. All interviews of first degree relatives and spouses were done blindly by a neurological resident. The operational diagnostic criteria of the International Headache Society were used.
Setting: General population from Copenhagen County.
Subjects: The 378 probands had 1109 first degree relatives and 229 spouses.
Main outcome measures: Patterns of familial aggregation of migraine with and without aura as assessed by calculation of the population relative risk.
Results: Compared with the general population the first degree relatives of probands with migraine without aura had 1.9 times the risk of migraine without aura and 1.4 times the risk of migraine with aura. The first degree relatives of probands with migraine with aura had nearly four times the risk of migraine with aura and no increased risk of migraine without aura. The first degree relatives of probands who had never had migraine had no increased risk of migraine either with or without aura. Spouses of probands with migraine without aura had 1.4 times the risk of migraine without aura whereas spouses of probands with migraine with aura had no increased risk of migraine with aura.
Conclusion: The different familial patterns indicate that migraine without aura and migraine with aura have a different aetiology. Migraine without aura seems to be caused by a combination of genetic and environmental factors whereas migraine with aura is probably determined largely or exclusively by genetic factors.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    StumbleUpon    Technorati    Twitter    What's this?

Relevant Articles

Diagnosis and management of alcohol use disorders

Andrew J R Parker, E Jane Marshall, and David M Ball
BMJ 2008 336: 496-501. [Extract] [Full Text] [PDF]

Migraine runs in families ..

W E Waters
BMJ 1995 311: 1227. [Extract] [Full Text]

This article has been cited by other articles:

• Scher, A. (2009). Comment on Rubino et al., 'Association of the C677T Polymorphism in the MTHFR Gene with Migraine: A Meta-Analysis'. Cephalalgia 29: 807-808 [Full text]  
• Ball, H., Samaan, Z, Brewster, S, Craddock, N, Gill, M, Korszun, A, Maier, W, Middleton, L, Mors, O, Owen, M., Perry, J, Preisig, M, Rice, J, Rietschel, M, Jones, L, Jones, I, Farmer, A., McGuffin, P (2009). Depression, Migraine With Aura and Migraine Without Aura: Their Familiality and Interrelatedness. Cephalalgia 29: 848-854 [Abstract] [Full text]  
• Bigal, M. (2009). Letters to the Editor. Cephalalgia 29: 799-799 [Full text]  
• Cha, Y-H, Lee, H, Santell, L., Baloh, R. (2009). Association of Benign Recurrent Vertigo and Migraine in 208 Patients. Cephalalgia 29: 550-555 [Abstract] [Full text]  
• Pezzini, A., Grassi, M., Del Zotto, E., Giossi, A., Monastero, R., Dalla Volta, G., Archetti, S., Zavarise, P., Camarda, C., Gasparotti, R., Magoni, M., Camarda, R., Padovani, A. (2007). Migraine Mediates the Influence of C677T MTHFR Genotypes on Ischemic Stroke Risk With a Stroke-Subtype Effect. Stroke 38: 3145-3151 [Abstract] [Full text]  
• Low, N., Cui, L, Merikangas, K. (2007). Sex Differences in the Transmission of Migraine. Cephalalgia 27: 935-942 [Abstract] [Full text]  
• Kaunisto, M., Kallela, M, Hamalainen, E, Kilpikari, R, Havanka, H, Harno, H, Nissila, M, Sako, E, Ilmavirta, M, Liukkonen, J, Teirmaa, H, Tornwall, O, Jussila, M, Terwilliger, J, Farkkila, M, Kaprio, J, Palotie, A, Wessman, M (2006). Testing of Variants of the MTHFR and ESR1 Genes in 1798 Finnish Individuals Fails to Confirm the Association with Migraine with Aura. Cephalalgia 26: 1462-1472 [Abstract] [Full text]  
• Monastero, R., Camarda, C., Pipia, C., Camarda, R. (2006). Prognosis of migraine headaches in adolescents: A 10-year follow-up study. Neurology 67: 1353-1356 [Abstract] [Full text]  
• Kirchmann, M., Thomsen, L. L., Olesen, J. (2006). Basilar-type migraine: Clinical, epidemiologic, and genetic features. Neurology 66: 880-886 [Abstract] [Full text]  
• Stewart, W. F., Bigal, M. E., Kolodner, K., Dowson, A., Liberman, J. N., Lipton, R. B. (2006). Familial risk of migraine: Variation by proband age at onset and headache severity. Neurology 66: 344-348 [Abstract] [Full text]  
• Hottenga, J., Vanmolkot, K., Kors, E., Kheradmand Kia, S, de Jong, P., Haan, J, Terwindt, G., Frants, R., Ferrari, M., van den Maagdenberg, A. (2005). The 3p21.1-p21.3 Hereditary Vascular Retinopathy Locus Increases the Risk for Raynaud's Phenomenon and Migraine. Cephalalgia 25: 1168-1172 [Abstract] [Full text]  
• Rose, K. M., Carson, A. P., Sanford, C. P., Stang, P. E., Brown, C. A., Folsom, A. R., Szklo, M. (2004). Migraine and other headaches: Associations with Rose angina and coronary heart disease. Neurology 63: 2233-2239 [Abstract] [Full text]  
• Endicott, N. (2004). Patterns of Functional Brain Organization and Migraine. Cephalalgia 24: 339-346 [Abstract] [Full text]  
• Thomsen, L., Ostergaard, E, Romer, S., Andersen, I, Eriksen, M., Olesen, J, Russell, M. (2003). Sporadic Hemiplegic Migraine is an Aetiologically Heterogeneous Disorder. Cephalalgia 23: 921-928 [Abstract] [Full text]  
• Siniatchkin, M, Kirsch, E, Arslan, S, Stegemann, S, Gerber, W-D, Stephani, U (2003). Migraine and Asthma in Childhood: Evidence for Specific Asymmetric Parent-Child Interactions in Migraine and Asthma Families. Cephalalgia 23: 790-802 [Abstract] [Full text]  
• Lea, R., Hilton, D., MacMillian, J., Griffiths, L. (2003). An Analysis of Clinical Characteristics in Genetically Linked Migraine-Affected Pedigrees. Cephalalgia 23: 808-813 [Abstract] [Full text]  
• Cader, Z. M., Noble-Topham, S., Dyment, D. A., Cherny, S. S., Brown, J. D., Rice, G. P.A., Ebers, G. C. (2003). Significant linkage to migraine with aura on chromosome 11q24. Hum Mol Genet 12: 2511-2517 [Abstract] [Full text]  
• Thomsen, L. L., Eriksen, M. K., Roemer, S. F., Andersen, I., Olesen, J., Russell, M. B. (2002). A population-based study of familial hemiplegic migraine suggests revised diagnostic criteria. Brain 125: 1379-1391 [Abstract] [Full text]  
• Russell, M. (2001). No Involvement of the Calcium Channel Gene (CACNA1A) in a Family with Cluster Headache. Cephalalgia 21: 939-939 [Full text]  
• Russell, M. (2001). Genetics of Migraine Without Aura, Migraine with Aura, Migrainous Disorder, Head Trauma Migraine Without Aura and Tension-Type Headache. Cephalalgia 21: 778-780 [Abstract] [Full text]  
• Tzourio, C., El Amrani, M., Poirier, O., Nicaud, V., Bousser, M.-G., Alperovitch, A. (2001). Association between migraine and endothelin type A receptor (ETA -231 A/G) gene polymorphism. Neurology 56: 1273-1277 [Abstract] [Full text]  
• Terwindt, G.M., Ophoff, R.A., van Eijk, R., Vergouwe, M.N., Haan, J., Frants, R.R., Sandkuijl, L.A., Ferrari, M.D. (2001). Involvement of the CACNA1A gene containing region on 19p13 in migraine with and without aura. Neurology 56: 1028-1032 [Abstract] [Full text]  
• Breslau, N., Rasmussen, B. K. (2001). The impact of migraine: Epidemiology, risk factors, and co-morbidities. Neurology 56: S4-S12 [Abstract] [Full text]  
• Dodick, D., Rozen, T., Goadsby, P., Silberstein, S. (2000). Cluster Headache. Cephalalgia 20: 787-803 [Abstract] [Full text]  
• Svensson, D., Larsson, B, Bille, B, Lichtenstein, P (1999). Genetic and Environmental Influences on Recurrent Headaches in Eight to Nine-Year-Old Twins. Cephalalgia 19: 866-872 [Abstract]  
• Launer, L. J., Terwindt, G. M., Ferrari, M. D. (1999). The prevalence and characteristics of migraine in a population-based cohort: The GEM Study. Neurology 53: 537-537 [Abstract] [Full text]  
• Russell, M., Ostergaard, S, Bendtsen, L, Olesen, J (1999). Familial Occurrence of Chronic Tension-Type Headache. Cephalalgia 19: 207-210 [Abstract]  
• Mitsikostas, D., Thomas, A. (1999). Comorbidity of Headache and Depressive Disorders. Cephalalgia 19: 211-217 [Abstract]  
• Ulrich, V., Gervil, M., Kyvik, K. O, Olesen, J., Russell, M. B (1999). The inheritance of migraine with aura estimated by means of structural equation modelling. J. Med. Genet. 36: 225-227 [Abstract] [Full text]  
• Waters, W E (1995). Migraine runs in families ... BMJ 311: 1227-1227 [Full text]