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Impact of massive dose of vitamin A given to preschool children with acute diarrhoea on subsequent respiratory and diarrhoeal morbidity

^a Division of Gastroenterology and Enteric Infections, Department of Paediatrics, All India Institute of Medical Sciences, New Delhi 110029, India

Correspondence to: Dr Bhan.

Abstract

Objective: To assess the impact of vitamin A supplementation on morbidity from acute respiratory tract infections and diarrhoea.
Design: Double blind randomised placebo controlled field trial.
Setting: An urban slum area in New Delhi, India. Subjects--900 children aged 12-60 months attending a local health facility for acute diarrhoea of less than seven days' duration randomly allocated to receive vitamin A 200000 IU or placebo.
Main outcome measures: Incidence and prevalence of acute lower respiratory tract infections and diarrhoea during the 90 days after termination of the enrolment diarrhoeal episode measured by twice weekly household surveillance.
Results: The incidence (relative risk 1.07; 95% confidence interval 0.92 to 1.26) and average number of days spent with acute lower respiratory tract infections were similar in the vitamin A supplementation and placebo groups. Among children aged 23 months or less there was a significant reduction in the incidence of measles (relative risk 0.06; 95% confidence interval 0.01 to 0.48). The incidence of diarrhoea was also similar (relative risk 0.95; 0.86 to 1.05) in the two groups. There was a 36% reduction in the mean daily prevalence of diarrhoea associated with fever in the vitamin A supplemented children older than 23 months.
Conclusions: Results were consistent with a lack of impact on acute lower respiratory tract related mortality after vitamin A supplementation noted in other trials and a possible reduction in the severity of diarrhoea.

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