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Association of apolipoprotein E phenotypes with late onset Alzheimer's disease: population based study

Departments of Medicine and Neurology, Kuopio University Hospital, Kuopio, Finland Department of Internal Medicine, Oulu University Hospital and Biocenter Oulu, University of Oulu, Oulu, Finland Correspondence to: Dr Laakso, Department of Medicine, University of Kuopio, 70210 Kuopio, Finland.

Abstract

Objective : To determine the association between the e4 allele of apolipoprotein E and Alzheimer's disease in a randomly selected population sample.
Design : Cross sectional population based study.
Subjects : 980 people aged 69 to 78 (349 men, 631 women).
Setting : Population of Kuopio, eastern Finland.
Main outcome measures : Presence of e4 allele and diagnosis of Alzheimer's disease by detailed neurological and neurophysiological evaluation.
Results : 46 (4.7%) subjects were classified as having probable or possible Alzheimer's disease. The frequency of the apolipoprotein E e4 allele was 0.359 in patients with Alzheimer's disease and 0.165 in subjects without dementia (P<0.0001). The prevalence of Alzheimer's disease was 2.9% in subjects with no e4 alleles, 7.6% in subjects with one e4 allele, and 21.4% in subjects with two e4 alleles of apolipoprotein E.
Conclusions : Allele e4 of apolipoprotein is associated with Alzheimer's disease in a dose-response fashion in a randomly selected elderly population.

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