BMJ  1992;304:1218-1222 (9 May), doi:10.1136/bmj.304.6836.1218

Hyponatraemia and death or permanent brain damage in healthy children.

University of California School of Medicine, San Francisco.

OBJECTIVE--To determine if hyponatraemia causes permanent brain damage in healthy children and, if so, if the disorder is primarily limited to females, as occurs in adults. DESIGN--Prospective clinical case study of 16 affected children and a review of 24,412 consecutive surgical admissions at one medical centre. PATIENTS--16 children (nine male, seven female; age 7 (SD 5) years) with generally minor illness were electively hospitalised for primary care. Consultation was obtained for the combination of respiratory arrest with symptomatic hyponatraemia (serum sodium concentration less than or equal to 128 mmol/l). MAIN OUTCOME MEASURES--Presence, gender distribution, and classification of permanent brain damage in children with symptomatic hyponatraemia in both prospective and retrospective studies. RESULTS--By retrospective evaluation the incidence of postoperative hyponatraemia among 24,412 patients was 0.34% (83 cases) and mortality of those afflicted was 8.4% (seven deaths). In the prospective population the serum sodium concentration on admission was 138 (SD 2) mmol/l. From three to 120 inpatient hours after hypotonic fluid administration patients developed progressive lethargy, headache, nausea, and emesis with an explosive onset of respiratory arrest. At the time serum sodium concentration was 115 (7) mmol/l and arterial oxygen tension 6 (1.5) kPa. The hyponatraemia was primarily caused by extrarenal loss of electrolytes with replacement by hypotonic fluids. All 16 patients had cerebral oedema detected at either radiological or postmortem examination. All 15 patients not treated for their hyponatraemia in a timely manner either died or were permanently incapacitated by brain damage. The only patient treated in a timely manner was alive but mentally retarded. CONCLUSIONS--Symptomatic hyponatraemia can result in high morbidity in children of both genders, which is due in large part to inadequate brain adaptation and lack of timely treatment.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    StumbleUpon    Technorati    What's this?

Relevant Article

Hyponatraemia in children.

M. Wright, P. de Silva, and S. Sinha
BMJ 1992 305: 51-52. [PDF]

This article has been cited by other articles:

• Ayus, J. C., Achinger, S. G., Arieff, A. (2008). Brain cell volume regulation in hyponatremia: role of sex, age, vasopressin, and hypoxia. Am. J. Physiol. Renal Physiol. 295: F619-F624 [Abstract] [Full text]  
• Beck, C. E. (2007). Hypotonic Versus Isotonic Maintenance Intravenous Fluid Therapy in Hospitalized Children: A Systematic Review. CLIN PEDIATR 46: 764-770 [Abstract]  
• Choong, K, Kho, M E, Menon, K, Bohn, D (2006). Hypotonic versus isotonic saline in hospitalised children: a systematic review. Arch. Dis. Child. 91: 828-835 [Abstract] [Full text]  
• Way, C., Dhamrait, R., Wade, A., Walker, I. (2006). Perioperative fluid therapy in children: a survey of current prescribing practice. Br J Anaesth 97: 371-379 [Abstract] [Full text]  
• Haycock, G. B (2006). HYPONATRAEMIA: DIAGNOSIS AND MANAGEMENT. EDUCATION AND PRACTICE 91: ep37-ep41 [Full text]  
• Hoorn, E.J., Halperin, M.L., Zietse, R. (2005). Diagnostic approach to a patient with hyponatraemia: traditional versus physiology-based options. QJM 98: 529-540 [Abstract] [Full text]  
• Hatherill, M (2004). Rubbing salt in the wound. Arch. Dis. Child. 89: 414-418 [Full text]  
• Taylor, D, Durward, A (2004). Pouring salt on troubled waters. Arch. Dis. Child. 89: 411-414 [Full text]  
• Moritz, M. L., Ayus, J. C. (2003). The pathophysiology and treatment of hyponatraemic encephalopathy: an update. Nephrol Dial Transplant 18: 2486-2491 [Full text]  
• GROSS, P., REIMANN, D., HENSCHKOWSKI, J., DAMIAN, M. (2001). Treatment of Severe Hyponatremia: Conventional and Novel Aspects. J. Am. Soc. Nephrol. 12: S10-S14 [Abstract] [Full text]  
• Arieff, A. I., Ayus, J. C. (1993). Endometrial Ablation Complicated by Fatal Hyponatremic Encephalopathy. JAMA 270: 1230-1232 [Abstract]  
• Ayus, J. C., Wheeler, J. M., Arieff, A. I. (1992). Postoperative Hyponatremic Encephalopathy in Menstruant Women. ANN INTERN MED 117: 891-897 [Abstract]  

Online poll

Find out more here>> and here>>