Medical Research Council trial of treatment of hypertension in older adults: principal results. MRC Working Party.

doi:10.1136/bmj.304.6824.405

BMJ 1992;304:405-412 (15 February), doi:10.1136/bmj.304.6824.405

Medical Research Council trial of treatment of hypertension in older adults: principal results. MRC Working Party.

OBJECTIVE--To establish whether treatment with diuretic or betablocker in hypertensive older adults reduces risk of stroke,coronary heart disease, and death. DESIGN--Randomised, placebocontrolled, single blind trial. SETTING--226 general practicesin the MRC general practice research framework. SUBJECTS--4396patients aged 65-74 randomised to receive diuretic, beta blocker,or placebo. Patients had mean systolic pressures of 160-209mm Hg and mean diastolic pressures less than 115 mm Hg duringan eight week run in and were not taking antihypertensive treatment.INTERVENTION--Patients were randomised to atenolol 50 mg daily;hydrochlorothiazide 25 mg or 50 mg plus amiloride 2.5 mg or5 mg daily; or placebo. The regimens were adjusted to achievespecified target pressures. Mean follow up was 5.8 years. MAINOUTCOME MEASURES--Strokes, coronary events, and deaths fromall causes. RESULTS--Both treatments reduced blood pressurebelow the level in the placebo group. Compared with the placebogroup, actively treated subjects (diuretic and beta blockergroups combined) had a 25% (95% confidence interval 3% to 42%)reduction in stroke (p = 0.04), 19% (-2% to 36%) reduction incoronary events (p = 0.08), and 17% (2% to 29%) reduction inall cardiovascular events (p = 0.03). After adjusting for baselinecharacteristics the diuretic group had significantly reducedrisks of stroke (31% (3% to 51%) p = 0.04), coronary events(44% (21% to 60%), p = 0.0009), and all cardiovascular events(35% (17% to 49%), p = 0.0005) compared with the placebo group.The beta blocker group showed no significant reductions in theseend points. The reduction in strokes was mainly in non-smokerstaking the diuretic. CONCLUSION--Hydrochlorothiazide and amiloridereduce the risk of stroke, coronary events, and all cardiovascularevents in older hypertensive adults.

Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Add to Reddit Reddit Add to StumbleUpon StumbleUpon Add to Technorati Technorati What's this?

Relevant Articles

MRC trial of treating hypertension in older adults.: K. Swedberg
BMJ 1992 304: 1630-1632. [PDF]

MRC trial of treating hypertension in older adults.: A. B. Mitchell
BMJ 1992 304: 1631-1632. [PDF]

MRC trial of treating hypertension in older adults.: J. Tuomilehto
BMJ 1992 304: 1631-1632. [PDF]

Treatment of hypertension in older adults.: J. A. Lewis
BMJ 1992 304: 1245. [PDF]

Elderly patients with sustained hypertension.: I. Aursnes
BMJ 1992 304: 1054. [PDF]

Treatment of hypertension in older adults.: M. J. Kendall
BMJ 1992 304: 639. [PDF]

This article has been cited by other articles:

Domanski, D., Schwarz, E. R. (2009). Clinical Review: Is the Perioperative Use of {beta}-Blockers Still Recommended? A Critical Review of Recent Controversies. J CARDIOVASC PHARMACOL THER 14: 258-268 [Abstract]
Fagard, R. H. (2009). Smoking Amplifies Cardiovascular Risk in Patients With Hypertension and Diabetes. Diabetes Care 32: S429-S431 [Full text]
Kaplan, N. M. (2009). The Choice of Thiazide Diuretics: Why Chlorthalidone May Replace Hydrochlorothiazide. Hypertension 54: 951-953 [Full text]
CHE, Q., SCHREIBER, M. J. JR, RAFEY, M. A. (2009). Beta-blockers for hypertension: Are they going out of style?. Cleveland Clinic Journal of Medicine 76: 533-542 [Abstract] [Full text]
Mackenzie, I. S., McEniery, C. M., Dhakam, Z., Brown, M. J., Cockcroft, J. R., Wilkinson, I. B. (2009). Comparison of the Effects of Antihypertensive Agents on Central Blood Pressure and Arterial Stiffness in Isolated Systolic Hypertension. Hypertension 54: 409-413 [Abstract] [Full text]
Wright, J. T. Jr, Probstfield, J. L., Cushman, W. C., Pressel, S. L., Cutler, J. A., Davis, B. R., Einhorn, P. T., Rahman, M., Whelton, P. K., Ford, C. E., Haywood, L. J., Margolis, K. L., Oparil, S., Black, H. R., Alderman, M. H., for the ALLHAT Collaborative Research Group, (2009). ALLHAT Findings Revisited in the Context of Subsequent Analyses, Other Trials, and Meta-analyses. Arch Intern Med 169: 832-842 [Abstract] [Full text]
Lujan, H. L., Palani, G., Chen, Y., Peduzzi, J. D., DiCarlo, S. E. (2009). Targeted ablation of cardiac sympathetic neurons reduces resting, reflex and exercise-induced sympathetic activation in conscious rats. Am. J. Physiol. Heart Circ. Physiol. 296: H1305-H1311 [Abstract] [Full text]
Kaplan, N. M. (2008). Beta-Blockers in Hypertension: Adding Insult to Injury. J Am Coll Cardiol 52: 1490-1491 [Full text]
Cutler, J. A., Davis, B. R. (2008). Thiazide-Type Diuretics and {beta}-Adrenergic Blockers as First-Line Drug Treatments for Hypertension. Circulation 117: 2691-2705 [Full text]
Beckett, N. S., Peters, R., Fletcher, A. E., Staessen, J. A., Liu, L., Dumitrascu, D., Stoyanovsky, V., Antikainen, R. L., Nikitin, Y., Anderson, C., Belhani, A., Forette, F., Rajkumar, C., Thijs, L., Banya, W., Bulpitt, C. J., the HYVET Study Group, (2008). Treatment of Hypertension in Patients 80 Years of Age or Older. NEJM 358: 1887-1898 [Abstract] [Full text]
Patel, A. B., Kostis, J. B., Wilson, A. C., Shea, M. L., Pressel, S. L., Davis, B. R. (2008). Long-Term Fatal Outcomes in Subjects With Stroke or Transient Ischemic Attack: Fourteen-Year Follow-Up of the Systolic Hypertension in the Elderly Program. Stroke 39: 1084-1089 [Abstract] [Full text]
Fagard, R. H., Staessen, J. A., Thijs, L., Celis, H., Bulpitt, C. J., de Leeuw, P. W., Leonetti, G., Tuomilehto, J., Yodfat, Y. (2007). On-Treatment Diastolic Blood Pressure and Prognosis in Systolic Hypertension. Arch Intern Med 167: 1884-1891 [Abstract] [Full text]
Bangalore, S., Messerli, F. H., Kostis, J. B., Pepine, C. J. (2007). Cardiovascular Protection Using Beta-Blockers: A Critical Review of the Evidence. J Am Coll Cardiol 50: 563-572 [Abstract] [Full text]
Authors/Task Force Members:, , Mancia, G., De Backer, G., Dominiczak, A., Cifkova, R., Fagard, R., Germano, G., Grassi, G., Heagerty, A. M., Kjeldsen, S. E., Laurent, S., Narkiewicz, K., Ruilope, L., Rynkiewicz, A., Schmieder, R. E., Struijker Boudier, H. A.J., Zanchetti, A., ESC Committee for Practice Guidelines (CPG):, , Vahanian, A., Camm, J., De Caterina, R., Dean, V., Dickstein, K., Filippatos, G., Funck-Brentano, C., Hellemans, I., Kristensen, S. D., McGregor, K., Sechtem, U., Silber, S., Tendera, M., Widimsky, P., Zamorano, J. L., ESH Scientific Council:, , Kjeldsen, S. E., Erdine, S., Narkiewicz, K., Kiowski, W., Agabiti-Rosei, E., Ambrosioni, E., Cifkova, R., Dominiczak, A., Fagard, R., Heagerty, A. M., Laurent, S., Lindholm, L. H., Mancia, G., Manolis, A., Nilsson, P. M., Redon, J., Schmieder, R. E., Struijker-Boudier, H. A.J., Viigimaa, M., Document Reviewers:, , Filippatos, G., Adamopoulos, S., Agabiti-Rosei, E., Ambrosioni, E., Bertomeu, V., Clement, D., Erdine, S., Farsang, C., Gaita, D., Kiowski, W., Lip, G., Mallion, J.-M., Manolis, A. J., Nilsson, P. M., O'Brien, E., Ponikowski, P., Redon, J., Ruschitzka, F., Tamargo, J., van Zwieten, P., Viigimaa, M., Waeber, B., Williams, B., Zamorano, J. L. (2007). 2007 Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Eur Heart J 0: ehm236v1-75 [Full text]
Chitravas, N., Dewey, H. M., Nicol, M. B., Harding, D. L., Pearce, D. C., Thrift, A. G. (2007). Is prestroke use of angiotensin-converting enzyme inhibitors associated with better outcome?. Neurology 68: 1687-1693 [Abstract] [Full text]
Ong, H T (2007). beta blockers in hypertension and cardiovascular disease. BMJ 334: 946-949 [Full text]
Eledrisi, M. S. (2007). First-Line Therapy for Hypertension. ANN INTERN MED 146: 615-615 [Full text]
Robinson, J. G., Bakris, G., Torner, J., Stone, N. J., Wallace, R. (2007). Is it Time for a Cardiovascular Primary Prevention Trial in the Elderly?. Stroke 38: 441-450 [Abstract] [Full text]
Pinto, E. (2007). Blood pressure and ageing. Postgrad. Med. J. 83: 109-114 [Abstract] [Full text]
Dzau, V. J., Antman, E. M., Black, H. R., Hayes, D. L., Manson, J. E., Plutzky, J., Popma, J. J., Stevenson, W. (2006). The Cardiovascular Disease Continuum Validated: Clinical Evidence of Improved Patient Outcomes: Part I: Pathophysiology and Clinical Trial Evidence (Risk Factors Through Stable Coronary Artery Disease). Circulation 114: 2850-2870 [Full text]
Sever, P., Dahlof, B., Poulter, N., Wedel, H., Beevers, G., Caulfield, M., Collins, R., Kjeldsen, S., Kristinsson, A., McInnes, G., Mehlsen, J., Nieminem, M., O'Brien, E., Ostergren, J., on behalf of the ASCOT Steering Committee Members, (2006). Potential synergy between lipid-lowering and blood-pressure-lowering in the Anglo-Scandinavian Cardiac Outcomes Trial. Eur Heart J 27: 2982-2988 [Abstract] [Full text]
Phillips, R. A. (2006). New-onset diabetes mellitus less deadly than elevated blood pressure?: following the evidence in the administration of thiazide diuretics.. Arch Intern Med 166: 2174-2176 [Full text]
Sawicki, P. T., McGauran, N. (2006). Have ALLHAT, ANBP2, ASCOT-BPLA, and So Forth Improved Our Knowledge About Better Hypertension Care?. Hypertension 48: 1-7 [Full text]
Sever, P. S., Poulter, N. R., Elliott, W. J., Jonsson, M. C., Black, H. R., Sever, P. S., Poulter, N. R., Elliott, W. J., Jonsson, M. C., Black, H. R. (2006). Blood Pressure Reduction Is Not the Only Determinant of Outcome. Circulation 113: 2754-2774 [Full text]
Khan, N., McAlister, F. A. (2006). Re-examining the efficacy of {beta}-blockers for the treatment of hypertension: a meta-analysis. CMAJ 174: 1737-1742 [Abstract] [Full text]
Sheridan, R., Baldwin, N. (2006). Impact of ASCOT on hypertension treatment and guidelines in older adults.. Age Ageing 35: 214-217 [Full text]
Zarnke, K. B (2006). Amlodipine plus perindopril was better than atenolol plus bendroflumethiazide for reducing complications in hypertension. Evid. Based Med. 11: 42-42 [Full text]
Prepared by: British Cardiac Society, British Hype, (2005). JBS 2: Joint British Societies' guidelines on prevention of cardiovascular disease in clinical practice. Heart 91: v1-v52 [Full text]
Ma, J., Albornoz, F., Yu, C., Byrne, D. W., Vaughan, D. E., Brown, N. J. (2005). Differing Effects of Mineralocorticoid Receptor-Dependent and -Independent Potassium-Sparing Diuretics on Fibrinolytic Balance. Hypertension 46: 313-320 [Abstract] [Full text]
Wang, J.-G., Staessen, J. A., Franklin, S. S., Fagard, R., Gueyffier, F. (2005). Systolic and Diastolic Blood Pressure Lowering as Determinants of Cardiovascular Outcome. Hypertension 45: 907-913 [Abstract] [Full text]
Haas, D. C., Foster, G. L., Nieto, F. J., Redline, S., Resnick, H. E., Robbins, J. A., Young, T., Pickering, T. G. (2005). Age-Dependent Associations Between Sleep-Disordered Breathing and Hypertension: Importance of Discriminating Between Systolic/Diastolic Hypertension and Isolated Systolic Hypertension in the Sleep Heart Health Study. Circulation 111: 614-621 [Abstract] [Full text]
Aronow, W. S. (2004). Management of the Elderly Person After Myocardial Infarction. Journals of Gerontology Series A: Biological Sciences and Medical Sciences 59: 1173-1185 [Abstract] [Full text]
Messerli, F. H., Fournier, A. (2004). Re: Lawes et al: Blood Pressure and Stroke. Stroke 35: 2238-2238 [Full text]
Sever, P. (2004). The VALUE trial: a commentary. Journal of Renin-Angiotensin-Aldosterone System 5: 99-101 [Abstract]
McEniery, C. M., Schmitt, M., Qasem, A., Webb, D. J., Avolio, A. P., Wilkinson, I. B., Cockcroft, J. R. (2004). Nebivolol Increases Arterial Distensibility In Vivo. Hypertension 44: 305-310 [Abstract] [Full text]
Psaty, B. M., Lumley, T., Furberg, C. D. (2004). Meta-analysis of Health Outcomes of Chlorthalidone-Based vs Nonchlorthalidone-Based Low-Dose Diuretic Therapies. JAMA 292: 43-44 [Full text]
Meredith, P. A, Murray, L. S, McMurray, J. J. (2004). A putative placebo comparison of the SCOPE and LIFE trials. Journal of Renin-Angiotensin-Aldosterone System 5: 59-63 [Abstract]
Fournier, A., Messerli, F. H., Achard, J. M., Fernandez, L. (2004). Cerebroprotection mediated by angiotensin II: A hypothesis supported by recent randomized clinical trials. J Am Coll Cardiol 43: 1343-1347 [Abstract] [Full text]
Messerli, F. H. (2004). Effects of Losartan in Hypertension without Vascular Disease. ANN INTERN MED 140: W-29-W-29 [Full text]
Lawes, C. M.M., Bennett, D. A., Feigin, V. L., Rodgers, A. (2004). Blood Pressure and Stroke: An Overview of Published Reviews. Stroke 35: 1024-1033 [Abstract] [Full text]
Lawes, C. M.M., Bennett, D. A., Feigin, V. L., Rodgers, A. (2004). Blood Pressure and Stroke: An Overview of Published Reviews. Stroke 35: 776-785 [Abstract] [Full text]
Carter, B. L., Ernst, M. E., Cohen, J. D. (2004). Hydrochlorothiazide Versus Chlorthalidone: Evidence Supporting Their Interchangeability. Hypertension 43: 4-9 [Abstract] [Full text]
O'Sullivan, C., Duggan, J., Lyons, S., Thornton, J., Lee, M., O'Brien, E. (2003). Hypertensive Target-Organ Damage in the Very Elderly. Hypertension 42: 130-135 [Abstract] [Full text]
Mcinnes, G. T (2003). `Size is not everything`: the Antihypertensive and Lipid-Lowering treatment to prevent Heart Attack Trial (ALLHAT): The ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. Major outcomes in high-risk hypertensive patients randomised to angiotensin-converting enzyme inhibitor or calcium channel blocker versus diuretic. The Antihypertensive and Lipid-Lowering treatment to prevent Heart Attack Trial (ALLHAT). British Journal of Diabetes & Vascular Disease 3: 263-267 [Abstract]
Psaty, B. M., Lumley, T., Furberg, C. D., Schellenbaum, G., Pahor, M., Alderman, M. H., Weiss, N. S. (2003). Health Outcomes Associated With Various Antihypertensive Therapies Used as First-Line Agents: A Network Meta-analysis. JAMA 289: 2534-2544 [Abstract] [Full text]
Hackam, D. G, Ashcroft, J. S (2003). Drug treatment of hypertension. BMJ 326: 764-764 [Full text]
Messerli, F. H (2003). The LIFE study: the straw that should break the camel's back. Eur Heart J 24: 487-489 [Full text]
Staessen, J. A, Wang, J.-G., Birkenhager, W. H (2003). Outcome beyond blood pressure control?. Eur Heart J 24: 504-514 [Full text]
Fournier, A., Oprisiu, R., Andrejak, M., Fernandez, L., Achard, J. M. (2003). Losartan vs Atenolol in Prevention of Stroke and Cardiovascular Disease. JAMA 289: 700-700 [Full text]
Messerli, F. H., Grossman, E., Fournier, A. (2003). Losartan vs Atenolol in Prevention of Stroke and Cardiovascular Disease. JAMA 289: 700-701 [Full text]
Terao, T., Messerli, F. H., Grossman, E., Ko, D. T., Hebert, P. R., Curtis, J. P., Krumholz, H. M., Sedrakyan, A., Coffey, C. S. (2002). {beta}-Blocker Therapy and Depression. JAMA 288: 1845-1846 [Full text]
Sharp, A., Mayet, J. (2002). Regression of left ventricular hypertrophy: hoping for a longer life. Journal of Renin-Angiotensin-Aldosterone System 3: 141-144 [Abstract]
ABAS, M., HOTOPF, M., PRINCE, M. (2002). Depression and mortality in a high-risk population: II-Year follow-up of the Medical Research Council Elderly Hypertension Trial. Br. J. Psychiatry 181: 123-128 [Abstract] [Full text]
Krum, H., Nolly, H., Workman, D., He, W., Roniker, B., Krause, S., Fakouhi, K. (2002). Efficacy of Eplerenone Added to Renin-Angiotensin Blockade in Hypertensive Patients. Hypertension 40: 117-123 [Abstract] [Full text]
Ko, D. T., Hebert, P. R., Coffey, C. S., Sedrakyan, A., Curtis, J. P., Krumholz, H. M. (2002). {beta}-Blocker Therapy and Symptoms of Depression, Fatigue, and Sexual Dysfunction. JAMA 288: 351-357 [Abstract] [Full text]
Sever, P. (2002). The SCOPE Trial. Journal of Renin-Angiotensin-Aldosterone System 3: 61-62 [Abstract]
Motwani, J. G (2002). Review: Combining renin-angiotensin-aldosterone system blockade with diuretic therapy for treatment of hypertension. Journal of Renin-Angiotensin-Aldosterone System 3: 72-78 [Abstract]
Boutitie, F., Gueyffier, F., Pocock, S., Fagard, R., Boissel, J. P., for the INDANA Project Steering Committee, (2002). J-Shaped Relationship between Blood Pressure and Mortality in Hypertensive Patients: New Insights from a Meta-Analysis of Individual-Patient Data. ANN INTERN MED 136: 438-448 [Abstract] [Full text]
Bobrie, G., Potter, J. F (2002). The elderly hypertensive population: what lies ahead of us?. Journal of Renin-Angiotensin-Aldosterone System 3: S4-S9
Blacher, J., Safar, M. (2002). Specific aspects of high blood pressure in the elderly. Journal of Renin-Angiotensin-Aldosterone System 3: S10-S15
Meredith, P. A, Trenkwalder, P. (2002). Therapy in the elderly hypertensive. Journal of Renin-Angiotensin-Aldosterone System 3: S49-S56 [Abstract]
Faergeman, O. (2002). Estimation and reduction of cardiovascular risk in old people. Eur Heart J 23: 261-263 [Full text]
Grossman, E, Messerli, F.H, Goldbourt, U (2001). Antihypertensive therapy and the risk of malignancies. Eur Heart J 22: 1343-1352 [Abstract]
Dalmay, F., Mazouz, H., Allard, J., Pesteil, F., Achard, J. M., Fournier, A. (2001). Non-AT1-receptor-mediated protective effect of angiotensin against acute ischaemic stroke in the gerbil. Journal of Renin-Angiotensin-Aldosterone System 2: 103-106 [Abstract]
Ebrahim, S. (2001). The Use of Numbers Needed to Treat Derived from Systematic Reviews and Meta-Analysis: Caveats and Pitfalls. Eval Health Prof 24: 152-164 [Abstract]
Nichols, W. W., Edwards, D. G. (2001). Arterial Elastance and Wave Reflection Augmentation of Systolic Blood Pressure: Deleterious Effects and Implications for Therapy. J CARDIOVASC PHARMACOL THER 6: 5-21 [Abstract]
Bulpitt, C. J (2001). Review: The management of the elderly with hypertension. Journal of Renin-Angiotensin-Aldosterone System 2: 11-13
Benetos, A., Thomas, F., Safar, M. E., Bean, K. E., Guize, L. (2001). Should diastolic and systolic blood pressure be considered for cardiovascular risk evaluation: a study in middle-aged men and women. J Am Coll Cardiol 37: 163-168 [Abstract] [Full text]
Opie, L. H. (2000). First line drugs in chronic stable effort angina--the case for newer, longer-acting calcium channel blocking agents. J Am Coll Cardiol 36: 1967-1971 [Abstract] [Full text]
Perry, H. M. Jr, Davis, B. R., Price, T. R., Applegate, W. B., Fields, W. S., Guralnik, J. M., Kuller, L., Pressel, S., Stamler, J., Probstfield, J. L., for the Systolic Hypertension in the Elderly Progr, (2000). Effect of Treating Isolated Systolic Hypertension on the Risk of Developing Various Types and Subtypes of Stroke: The Systolic Hypertension in the Elderly Program (SHEP). JAMA 284: 465-471 [Abstract] [Full text]
Lam, T. H., Liu, J. L. Y., Tang, J.-l., McBride, P. E., Stein, J. H., Kumana, C. R., Cheung, B. M. Y., Lauder, I. J. (2000). Assessing Prevention Interventions by "Number Needed to Treat". JAMA 284: 303-305 [Full text]
Cruickshank, J.M (2000). Beta-blockers continue to surprise us. Eur Heart J 21: 354-364
Lesser, G. T., Libow, L. S., Rochon, P. A., Gurwitz, J. H. (2000). Prescribing for Elderly Persons. JAMA 283: 339-340 [Full text]
Frohlich, E. D. (1999). The necessity for recognition and treatment of patients with "mild" hypertension. J Am Coll Cardiol 34: 1369-1377 [Abstract] [Full text]
Chen, C.-H., Nakayama, M., Nevo, E., Fetics, B. J., Maughan, W. L., Kass, D. A. (1998). Coupled systolic-ventricular and vascular stiffening with age: Implications for pressure regulation and cardiac reserve in the elderly. J Am Coll Cardiol 32: 1221-1227 [Abstract] [Full text]
Pepine, C. J., Handberg-Thurmond, E., Marks, R. G., Conlon, M., Cooper-Dehoff, R., Volkers, P., Zellig, P., for The INVEST Investigators, (1998). Rationale and design of the International Verapamil SR/Trandolapril Study (INVEST): an Internet-based randomized trial in coronary artery disease patients with hypertension. J Am Coll Cardiol 32: 1228-1237 [Abstract] [Full text]
Messerli, F. H., Grossman, E., Goldbourt, U. (1998). Are {beta}-Blockers Efficacious as First-line Therapy for Hypertension in the Elderly?: A Systematic Review. JAMA 279: 1903-1907 [Abstract] [Full text]
(1997). The Sixth Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Arch Intern Med 157: 2413-2446 [Abstract]
Kostis, J. B., Davis, B. R., Cutler, J., Grimm, R. H. Jr, Berge, K. G., Cohen, J. D., Lacy, C. R., Perry, H. M. Jr, Blaufox, M. D., Wassertheil-Smoller, S., Black, H. R,, Schron, E., Berkson, D. M., Curb, J. D., Smith, W. M., McDonald, R., Applegate, W. B. (1997). Prevention of Heart Failure by Antihypertensive Drug Treatment in Older Persons With Isolated Systolic Hypertension. JAMA 278: 212-216 [Abstract]
Michalewiz, L., Chambers, R., Grodzicki, T. (1997). Primary Prevention of Cardiovascular Disease Endpoints Using {beta}-Blockers. JAMA 277: 1759-1759 [Abstract]
Kelly, D. T. (1997). 1996 Paul Dudley White International Lecture : Our Future Society: A Global Challenge. Circulation 95: 2459-2464 [Full text]
Psaty, B. M., Smith, N. L., Siscovick, D. S., Koepsell, T. D., Weiss, N. S., Heckbert, S. R., Lemaitre, R. N., Wagner, E. H., Furberg, C. D. (1997). Health Outcomes Associated With Antihypertensive Therapies Used as First-Line Agents: A Systematic Review and Meta-analysis. JAMA 277: 739-745 [Abstract]
DeQuattro, V., Li, D. (1997). Antihypertensive Therapy in Patients Undergoing Noncardiac Surgery. J CARDIOVASC PHARMACOL THER 2: 331-335 [Abstract]
Curb, J. D., Pressel, S. L., Cutler, J. A., Savage, P. J., Applegate, W. B., Black, H., Camel, G., Davis, B. R., Frost, P. H., Gonzalez, N., Guthrie, G., Oberman, A., Rutan, G. H., Stamler, J. (1996). Effect of Diuretic-Based Antihypertensive Treatment on Cardiovascular Disease Risk in Older Diabetic Patients With Isolated Systolic Hypertension. JAMA 276: 1886-1892 [Abstract]
Borhani, N. O., Mercuri, M., Borhani, P. A., Buckalew, V. M., Canossa-Terris, M., Carr, A. A., Kappagoda, T., Rocco, M. V., Schnaper, H. W., Sowers, J. R., Bond, M. G. (1996). Final Outcome Results of the Multicenter Isradipine Diuretic Atherosclerosis Study (MIDAS) A Randomized Controlled Trial. JAMA 276: 785-791 [Abstract]
Vasan, R. S., Levy, D. (1996). The Role of Hypertension in the Pathogenesis of Heart Failure: A Clinical Mechanistic Overview. Arch Intern Med 156: 1789-1796 [Abstract]
(1996). Too many beta-blockers. DTB 34: 49-52 [Abstract] [Full text]
Grimm, R. H. Jr, Flack, J. M., Grandits, G. A., Elmer, P. J., Neaton, J. D., Cutler, J. A., Lewis, C., McDonald, R., Schoenberger, J., Stamler, J., Treatment of Mild Hypertension Study (TOMHS) Resea, (1996). Long-term Effects on Plasma Lipids of Diet and Drugs to Treat Hypertension. JAMA 275: 1549-1556 [Abstract]
Lewis, C. E., Grandits, G. A., Flack, J., McDonald, R., Elmer, P. J. (1996). Efficacy and Tolerance of Antihypertensive Treatment in Men and Women With Stage 1 Diastolic Hypertension: Results of the Treatment of Mild Hypertension Study. Arch Intern Med 156: 377-385 [Abstract]
Corson, J. D., Mohan, C. R., Hoballah, J. J., Sharp, W. J., Kresowik, T. F. (1996). Atherosclerosis and Risk Factor Modification: Does It Really Make a Difference?. PERSPECT VASC SURG ENDOVASC THER 9: 75-94
Pearce, K. A., Furberg, C. D., Rushing, J. (1995). Does Antihypertensive Treatment of the Elderly Prevent Cardiovascular Events or Prolong Life? A Meta-analysis of Hypertension Treatment Trials. Arch Fam Med 4: 943-949 [Abstract]
Glynn, R. J., Brock, D. B., Harris, T., Havlik, R. J., Chrischilles, E. A., Ostfeld, A. M., Taylor, J. O., Hennekens, C. H. (1995). Use of Antihypertensive Drugs and Trends in Blood Pressure in the Elderly. Arch Intern Med 155: 1855-1860 [Abstract]
Psaty, B. M., Heckbert, S. R., Koepsell, T. D., Siscovick, D. S., Raghunathan, T. E., Weiss, N. S., Rosendaal, F. R., Lemaitre, R. N., Smith, N. L., Wahl, P. W., Wagner, E. H., Furberg, C. D. (1995). The Risk of Myocardial Infarction Associated With Antihypertensive Drug Therapies. JAMA 274: 620-625 [Abstract]
Psaty, B. M., Koepsell, T. D., Yanez, N. D., Smith, N. L., Manolio, T. A., Heckbert, S. R., Borhani, N. O., Gardin, J. M., Gottdiener, J. S., Rutan, G. H., Siscovick, D. S., Furberg, C. D. (1995). Temporal Patterns of Antihypertensive Medication Use Among Older Adults, 1989 Through 1992: An Effect of the Major Clinical Trials on Clinical Practice?. JAMA 273: 1436-1438 [Abstract]