Br Med J (Clin Res Ed)  1985;291:235-238 (27 July), doi:10.1136/bmj.291.6490.235

Lack of effect of oral magnesium on high blood pressure: a double blind study.

F P Cappuccio, N D Markandu, G W Beynon, A C Shore, B Sampson, G A MacGregor

Seventeen unselected patients with mild to moderate essential hypertension and whose average supine blood pressure after two months' observation with no treatment was 154/100 mm Hg were entered into a double blind randomised crossover study of one month's treatment with magnesium aspartate (15 mmol magnesium/day) and treatment with placebo for a further month. This preparation of magnesium was well tolerated and did not cause diarrhoea. Despite a significant increase in plasma magnesium concentration and a significant increase in urinary excretion of magnesium while taking magnesium aspartate there was no fall in blood pressure compared with either treatment with placebo or values before treatment. The results provide no evidence for a role of dietary magnesium in the regulation of high blood pressure and are contrary to recent speculations.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to StumbleUpon StumbleUpon   Add to Technorati Technorati    What's this?

This article has been cited by other articles:

  • Champagne, C. M. (2008). Magnesium in Hypertension, Cardiovascular Disease, Metabolic Syndrome, and Other Conditions: A Review. Nutr Clin Pract 23: 142-151 [Abstract] [Full text]  
  • Touyz, R. M. (2008). Transient receptor potential melastatin 6 and 7 channels, magnesium transport, and vascular biology: implications in hypertension. Am. J. Physiol. Heart Circ. Physiol. 294: H1103-H1118 [Abstract] [Full text]  
  • Bo, S., Durazzo, M., Guidi, S., Carello, M., Sacerdote, C., Silli, B., Rosato, R., Cassader, M., Gentile, L., Pagano, G. (2006). Dietary magnesium and fiber intakes and inflammatory and metabolic indicators in middle-aged subjects from a population-based cohort.. Am. J. Clin. Nutr. 84: 1062-1069 [Abstract] [Full text]  
  • Sacks, F. M., Willett, W. C., Smith, A., Brown, L. E., Rosner, B., Moore, T. J. (1998). Effect on Blood Pressure of Potassium, Calcium, and Magnesium in Women With Low Habitual Intake. Hypertension 31: 131-138 [Abstract] [Full text]  
  • Lardinois, C. K. (1995). Nutritional Factors and Hypertension. Arch Fam Med 4: 707-713 [Abstract]  
  • Purvis, J. R., Cummings, D. M., Landsman, P., Carroll, R., Barakat, H., Bray, J., Whitley, C., Horner, R. D. (1994). Effect of Oral Magnesium Supplementation on Selected Cardiovascular Risk Factors in Non--Insulin-Dependent Diabetics. Arch Fam Med 3: 503-508 [Abstract]  
  • (1993). National High Blood Pressure Education Program Working Group Report on Primary Prevention of Hypertension. Arch Intern Med 153: 186-208 [Abstract]  
  • The Trials of Hypertension Prevention Collaborativ, , Members of the Trials of Hypertension Prevention C, , Clinical Centers, , Whelton, P. K., Appel, L., Charleston, J., Dalcin, A. T., Ewart, C., Fried, L., Kaidy, D., Klag, M. J., Kumanyika, S., Steffen, L., Walker, W. G., Oberman, A., Counts, K., Hataway, H., Raczynski, J., Rappaport, N., Weinsier, R., Borhani, N. O., Bernauer, E., Borhani, P., de la Cruz, C., Ertl, A., Heustis, D., Lee, M., Lovelace, W., O'Connor, E., Peel, L., Sugars, C., Taylor, J. O., Corkery, B. W., Evans, D. A., Keough, M. E., Morris, M. C., Pistorino, E., Sacks, F., Cameron, M., Corrigan, S., Wright, N. K., Applegate, W. B., Brewer, A., Goodwin, L., Miller, S., Murphy, J., Randle, J., Sullivan, J., Lasser, N. L., Batey, D. M., Dolan, L., Hamill, S., Kennedy, P., Lasser, V. I., Kuller, L. H., Caggiula, A. W., Milas, N. C., Yamamoto, M. E., Vogt, T. M., Greenlick, M. R., Hollis, J., Stevens, V., Cohen, J. D., Mattfeldt-Beman, M., Brinkmann, C., Roth, K., Shepek, L., Coordinating Center, , Hennekens, C. H., Buring, J., Cook, N., Danielson, E., Eberlein, K., Gordon, D., Hebert, P., MacFadyen, J., Mayrent, S., Rosner, B., Satterfield, S., Tosteson, H., Van Denburgh, M., Project Office, , Cutler, J. A., Brittain, E., Farrand, M., Kaufmann, P., Lakatos, E., Obarzanek, E., Central Laboratory, , Belcher, J., Dommeyer, A., Mills, I., Neibling, P., Nutrient Data Center, , Woods, M., Goldman, B.J. K., Blethen, E., Sacks, F. (1992). The Effects of Nonpharmacologic Interventions on Blood Pressure of Persons With High Normal Levels: Results of the Trials of Hypertension Prevention, Phase I. JAMA 267: 1213-1220 [Abstract]  
Access jobs at BMJ Careers
Whats new online at Student BMJ