Br Med J (Clin Res Ed)  1984;289:1492-1494 (1 December), doi:10.1136/bmj.289.6457.1492

Influence of non-steroidal anti-inflammatory drugs on diuretic treatment of mild to moderate essential hypertension.

P P Koopmans, T Thien, F W Gribnau

In an open triple crossover study in 10 patients with mild to moderate essential hypertension the influence was investigated of adding indomethacin 50 mg, naproxen 250 mg, or sulindac 200 mg, each twice daily for four weeks, to diuretic treatment with hydrochlorothiazide 50 mg a day. After two weeks' treatment with indomethacin a slight increase in blood pressure was observed, whereas both sulindac and naproxen tended to enhance the antihypertensive effect of hydrochlorothiazide. After treatment for four weeks, however, the effects of all three drugs on blood pressure appeared to be blunted. Furthermore, body weight increased significantly during treatment with indomethacin but not during treatment with naproxen or sulindac. No significant changes were found for various biochemical variables, including concentrations of plasma electrolytes and serum creatinine and albumin, plasma renin activity, plasma aldosterone concentration, and 24 hour urinary excretion of sodium and potassium, with the exception, however, of an increase in plasma potassium concentration during treatment with indomethacin. These observations suggest that the interaction of indomethacin, naproxen, and sulindac with diuretic treatment in mild to moderate essential hypertension is transient and of minor clinical importance.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to StumbleUpon StumbleUpon   Add to Technorati Technorati    What's this?

This article has been cited by other articles:

  • Houston, M. C., Weir, M., Gray, J., Ginsberg, D., Szeto, C., Kaihlenen, P. M., Sugimoto, D., Runde, M., Lefkowitz, M. (1995). The Effects of Nonsteroidal Anti-inflammatory Drugs on Blood Pressures of Patients With Hypertension Controlled by Verapamil. Arch Intern Med 155: 1049-1054 [Abstract]  
  • Zell, S. C., Lardinois, C. K. (1993). Treatment of Mild Hypertension: Decision Before Drugs. Arch Fam Med 2: 778-786 [Abstract]  
  • Pope, J. E., Anderson, J. J., Felson, D. T. (1993). A Meta-analysis of the Effects of Nonsteroidal Anti-inflammatory Drugs on Blood Pressure. Arch Intern Med 153: 477-484 [Abstract]  
Access jobs at BMJ Careers
Whats new online at Student BMJ