Serum Growth Hormone Levels and the Response of Diabetic Retinopathy to Pituitary Ablation

doi:10.1136/bmj.2.5653.346

Br Med J 1969;2:346-348 (10 May), doi:10.1136/bmj.2.5653.346

Serum Growth Hormone Levels and the Response of Diabetic Retinopathy to Pituitary Ablation^*

A. D. Wright, E. M. Kohner, N. W. Oakley, M. Hartog, G. F. Joplin, T. Russell Fraser

Serum growth hormone levels were measured during insulin tolerancetests in 36 patients after yttrium-90 pituitary implantationfor diabetic retinopathy. The response of the new blood vesselswas more clearly related to loss of growth hormone functionthan was the improvement of retinal haemorrhages and microaneurysms.The overall response of the retinopathy was greatest when growthhormone function was lost.

Since the loss of growth hormone function was related to theloss of other aspects of anterior pituitary function, a uniquerole of growth hormone in the response of diabetic retinopathyto pituitary ablation could not be established.

^* Based on a paper read to the Spring Meeting of the Medical-ScientificSection of the British Diabetic Association, Oxford, 1968.

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