Table 4 Incidence of admission to hospital for hepatopathies and for liver injury,
and rate ratios, among current users of non-steroidal anti-inflammatory
drugs*
|
|
|
All hepatopathies
|
Liver injury
|
Drug
|
Current use (person years)
|
No of events
|
Rates per 100 000 person years
|
Crude rate ratios (95% CI)
|
No of events
|
Rates per 100 000 person years
|
Crude rate ratios (95% CI)
|
Nimesulide
|
48 294
|
17
|
35.2
|
1.9 (1.1 to 3.3)
|
16
|
33.1
|
2.2 (1.3 to 3.9)
|
Diclofenac
|
35 760
|
14
|
39.2
|
2.1 (1.2 to 3.8)
|
8
|
22.4
|
1.5 (0.7 to 3.2)
|
Piroxicam
|
22 051
|
5
|
22.7
|
1.2 (0.5 to 3.1)
|
4
|
13.6
|
1.2 (0.4 to 3.4)
|
Ketoprofen
|
19 848
|
5
|
25.2
|
1.4 (0.6 to 3.4)
|
4
|
20.2
|
1.4 (0.5 to 3.8)
|
Ketorolac
|
5992
|
4
|
66.8
|
3.7 (1.3 to 10.0)
|
2
|
33.4
|
2.3 (0.6 to 9.2)
|
Ibuprofen
|
4482
|
2
|
44.6
|
2.4 (0.6 to 10.0)
|
2
|
44.6
|
3.0 (0.7 to 12.4)
|
Naproxen
|
7833
|
2
|
25.5
|
1.4 (0.3 to 5.7)
|
1
|
12.8
|
0.9 (0.1 to 6.2)
|
Celecoxib
|
6619
|
1
|
15.1
|
0.8 (0.1 to 6.6)
|
1
|
15.1
|
1.0 (0.1 to 7.3)
|
Meloxicam
|
4232
|
1
|
23.6
|
1.3 (0.2 to 8.1)
|
—
|
—
|
—
|
Cinnoxicam
|
1541
|
1
|
64.9
|
3.6 (0.2 to 12.5)
|
1
|
64.9
|
4.4 (0.3 to 13.7)
|
Flurbiprofen
|
1022
|
1
|
97.8
|
5.4 (0.3 to 14.9)
|
1
|
97.8
|
6.6 (0.3 to 13.4)
|
Past use
|
378 433
|
69
|
18.2
|
1.0
|
56
|
14.8
|
1.0
|
|
Patients who received more than one non-steroidal anti-inflammatory drug
during current period (mixed use) are included in counts of each subsequent
drug.
* Non-steroidal anti-inflammatory drugs with at least one event among current
users shown.