Impact of zinc supplementation on acute lower respiratory infections, pneumonia, and admissions to hospital for all causes in children aged 6-35 months during four months of follow up
Zinc
Placebo
Absolute risk reduction (95% CI)
Odds ratio
*
(95% CI)
Child based analysis
No of children
1241
1241
No (%) with
1 episodes of acute lower respiratory tract infections
425 (34.2)
423 (34.1)
0.2% (
3.9% to 3.6%)
No (%) with
1 episodes of pneumonia
81 (6.5)
112 (9.0)
2.5% (0.4% to 4.6%)
No (%) admitted to hospital for any cause
21 (1.8)
30 (2.4)
0.6% (
0.5% to 1.8%)
Person time based analysis
No of four month child periods
1100
1120
Acute lower respiratory tract infections:
Total episodes
581
594
Episodes per four month period
0.53
0.54
1% (
2.9% to 5%)
0.98 (0.86 to 1.13)
Pneumonia:
Total episodes
88
118
Episodes per four month period
0.08
0.105
2.4% (0.2% to 4.6%)
0.74 (0.56 to 0.99)
*
After correction for correlation of data by generalised estimating equations.
Person time for each child was calculated as total follow up days when reliable informant was available.