Impact of zinc supplementation on acute lower respiratory infections, pneumonia, and admissions to hospital for all causes in children aged 6-35 months during four months of follow up


Zinc
Placebo
Absolute risk reduction (95% CI)
Odds ratio* (95% CI)
Child based analysis
No of children 1241 1241 --- ---
No (%) with >= 1 episodes of acute lower   respiratory tract infections 425 (34.2) 423 (34.1) -0.2% (-3.9% to 3.6%) ---
No (%) with >= 1 episodes of pneumonia 81 (6.5) 112 (9.0) 2.5% (0.4% to 4.6%) ---
No (%) admitted to hospital for any cause 21 (1.8) 30 (2.4)  0.6% (-0.5% to 1.8%) ---
Person time based analysisdagger
No of four month child periods 1100 1120 ---
Acute lower respiratory tract infections:
  Total episodes 581 594 ---
  Episodes per four month period 0.53 0.54  1% (-2.9% to 5%) 0.98 (0.86 to 1.13)
Pneumonia:
  Total episodes 88 118 ---
  Episodes per four month period 0.08 0.105 2.4% (0.2% to 4.6%) 0.74 (0.56 to 0.99)

* After correction for correlation of data by generalised estimating equations.
dagger Person time for each child was calculated as total follow up days when reliable informant was available.