Table 1.
Burden of disease and evidence from randomised controlled trials for main categories of human disease in sub-Saharan Africa
Disease category
Burden of disease in 2000 (1000 DALYs)
No of trials (No before 1990)
No of participants
Ratio of burden of disease (1000 DALYs)
Per trial
Per participant
Infectious and parasitic diseases
131 327
540 (183)
813 305
243
0.16
Respiratory infections
29 077
18 (7)
52 811
1615
0.55
Maternal conditions
5 691
85 (30)
25 148
67
0.23
Conditions arising during perinatal period
18 700
30 (8)
28 381
623
0.66
Nutritional deficiencies
8 389
105 (37)
111 922
80
0.07
Malignant neoplasms
8 114
46 (30)
128 786
176
0.06
Diabetes mellitus
522
13 (9)
1 276
40
0.41
Endocrine disorders
1 168
10 (8)
287
117
4.07
Neuropsychiatric conditions
15 788
41 (21)
3 580
385
4.41
Sense organ diseases
2 460
10 (2)
607
246
4.05
Cardiovascular diseases
13 390
99 (59)
5 648
135
2.37
Respiratory diseases
9 037
33 (13)
3 320
274
2.72
Digestive diseases
5 418
76 (48)
5 545
71
0.98
Genitourinary diseases
2 651
34 (15)
1 903
78
1.39
Skin diseases
*
6 (3)
407
Musculoskeletal diseases
1 404
27 (22)
1 536
52
0.91
Congenital anomalies
5 224
2 (0)
1 321
2612
3.95
Oral conditions
534
18 (8)
3 567
30
0.15
Injuries
58 352
31 (19)
2 887
1882
20.21
*
Burden of disease considered small, no exact data given.
Data are not shown for 48 trials (32 published before 1990) that examined topics such as analgesia and anaesthesia that cannot be categorised under the global burden of disease taxonomy.
