Appendix 1:

MEDLINE search strategy


The search strategy gathers together the references from the five potential areas of MEDLINE where they could be found, restricts them to english language publications on human adults and then looks for the study designs meta-analysis, randomised controlled trials, cohort studies and case control studies. In each case the study design is included as a MeSH heading and a text word.

1. exp asthma/

2. exp peak expiratory flow rate/

3. exp lung diseases, obstructive/

4. exp forced expiratory volume/

5.exp dyspnea, paroxysmal/

6.1 or 2 or 3

7.4 not 6

8.5 or 7

9.6 not 8

10.limit 9 to english language

11.limit 10 to human

12.limit 11 to (adult <19 to 44 years> or middle age <45 to 64 years> or aged <65 to 79 years> or "aged, 80 and over")

13.limit 12 to meta analysis

14.exp meta-analysis/

15.12 and 14

16.meta analys:.tw.

17.12 and 16

18.13 or 15 or 17

19.limit 12 to randomized controlled trial

20.random:.tw.

21.12 and 20

22.19 or 21

23.limit 12 to (review or review literature or review of reported cases or review, academic or review, multicase or review, tutorial or scientific integrity review)

24.review.tw.

25.12 and 24

26.23 or 25

27.exp cohort studies/

28.12 and 27

29.cohort.tw.

30.12 and 29

31.28 and 30

32.exp case-control studies/

33.12 and 32

34.case control.tw.

35.12 and 34

36.33 or 35

37.18 or 22 or 26 or 31 or 36