Appendix 2

MEDLINE search strategy

The search strategy gathers together the references from the five potential areas of MEDLINE where they could be found, restricts them to english language publications on human adults and then looks for the study designs: meta-analysis, randomised controlled trial, cohort studies and case control studies. In each case the study design is included as a MeSH heading and a text word.

1. exp coronary disease/

2. exp angina pectoris/

3. exp coronary aneurysm/

4. exp coronary vasospasm/

5. 1 or 2

6. 3 or 4

7. 5 not 6

8. limit 7 to english language

9. limit 8 to human

10. limit 9 to (adult <19 to 44 years> or middle age <45 to 64 years> or aged <65 to 79 years> or "aged, 80 and over")

11. limit 10 to meta analysis

12. exp meta-analysis/

13. 10 and 12

14. meta-analysis.tw.

15. 10 and 14

16. 11 or 13 or 15

17. limit 10 to randomised controlled trial

18. random:.tw.

19. 10 and 18

20. 17 or 19

21. limit 10 to (review or review literature or review of reported cases or review, academic or review, multicase or review, tutorial or scientific integrity review)

22. review.tw.

23. 10 and 22

24. 21 or 23

25. exp cohort studies/

26. 10 and 25

27. cohort.tw.

28. 10 and 27

29. 26 or 28

30. exp case-control studies/

31. 10 and 30

32. case control.tw.

33. 10 and 32

34. 31 or 33

35. 16 or 20 or 24 or 29 or 34