- R J Heald, surgical director (Completeresponse@pelicancancer.org)1,
- Brian D P O'Neill, clinical oncology research fellow2,
- Brendan Moran, consultant surgeon2,
- Gina Brown, consultant radiologist3,
- Ara W Darzi, honorary consultant3,
- Andrew C Wotherspoon, consultant histopathologist3,
- David Cunningham, consultant medical oncologist3,
- Diana M Tait, consultant medical oncologist3
- 1 Pelican Cancer Foundation, Basingstoke RG24 9NA
- 2 Pelican Cancer Foundation, Basingstoke RG24 9NA,
- 3 Royal Marsden NHS Foundation Trust, London SW3 6JJ
EDITOR—Tumour shrinkage by preoperative chemoradiotherapy is now an everyday reality, and pathological complete responses are not uncommon.1 A “new dilemma” is posed by the apparent complete disappearance of cancer on magnetic resonance imaging, and often clinically, after chemoradiotherapy. A delay of six to 10 weeks is usual before operating—a time perceived as a “window of opportunity,” as regrowth in the irradiated area …
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