Letter

Fluoroquinolone resistance in Salmonella Typhi

BMJ 2006; 333 doi: 10.1136/bmj.333.7563.353-b (Published 10 August 2006)
Cite this as: BMJ 2006;333:353.3

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  1. Fiona J Cooke (fiona@sanger.ac.uk), MRC clinical research training fellow,
  2. John Wain, member of faculty,
  3. E John Threlfall, professor
  1. Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA
  2. Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA
  3. Health Protection Agency, Centre for Infections, London NW9 5HT

    EDITOR—As Parry et al point out,12 appropriate laboratory methods are crucial in detecting clinically important quinolone resistance.

    We highlight the emergence of strains of Salmonella enterica serovar Typhi (S Typhi) that show reduced susceptibility to the fluoroquinolones but are susceptible to nalidixic acid (minimum inhibitory concentration < 16 mg/l). In a review of all 692 isolates of S Typhi sent to the Laboratory …

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