EDITOR—The paper by Plowe et al entitled “Sustained clinical efficacy of sulfadoxine-pyrimethamine for uncomplicated falciparum malaria” might be better titled “Sustained lack of efficacy of sulfadoxine-pyrimethamine….”1 By the start of the study period five years ago, molecular genotyping showed that Plasmodium falciparum in Malawi had already acquired significant resistance to the combination.1 2 This explains the sustained lack of efficacy; …