EDITOR—There were some enthusiastic champions of the concept, but, overall, respondents remained to be convinced that the “Polypill” issue was indeed a collector's item and a possible contender for the most important BMJ paper in 50 years, as the editor had indicated.1^–5 Images of the tooth fairy and April foolery were invoked, along with gasps of horror, astonishment, and incredulity that the hypothesis should be taken for anything approaching rigorous science.

This was proof, if any were needed, that the BMJ had finally lost the plot, judged several contributors.

Chief among the concerns was the lack of trial evidence for the effectiveness of the Polypill, or any facsimile, for that matter. Wasn't …