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  1. Nicholas J Wald,
  2. David J H Brock,
  3. James E Haddow,
  4. Richard A Doherty
  1. Professor Wolfson Institute of Preventive Medicine, Medical College of St Bartholomew's Hospital, London EC1M 6BQ
  2. Professor Department of Medicine, Human Genetics Unit, Western General Hospital, Edinburgh EH4 2XU
  3. Medical director Director of clinical genetics Foundation for Blood Research, PO Box 190, Scarborough, ME 04074, USA

    EDITOR,—Zosia H Miedzybrodzka and colleagues' claim that stepwise screening for cystic fibrosis is better than couple screening is unjustified.1 Antenatal screening for cystic fibrosis should minimise the number of women identified as being at high risk for a given proportion of affected pregnancies detected and should ensure that a diagnostic test is available for everyone defined as being at high risk. Stepwise screening …

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