Letter

Other American studies fail to confirm an association

BMJ 1995; 310 doi: 10.1136/bmj.310.6985.1009c (Published 15 April 1995)
Cite this as: BMJ 1995;310:1009.4

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  1. Shelia Hoar Zahm,
  2. Aaron Blair,
  3. Kenneth P Cantor,
  4. Joseph F Fraumeni Jr
  1. Epidemiologist, occupational studies section Chief, occupational studies section Epidemiologist, environmental studies section Associate director Epidemiology and Biostatistics Programme, National Cancer Institute, EPN 418, Rockville, MD 20892-7364, USA

    EDITOR,—Toshiki Natazuka and colleagues report an association between non-insulin dependent diabetes mellitus and non-Hodgkin's lymphoma.1 They suggest that as diabetes mellitus impairs the immune response to infectious agents it might increase the risk of non-Hodgkin's lymphoma, which is associated with immunodeficiency states. By comparing the observed frequency of diabetes in a hospital case series with that expected on the basis of the prevalence of diabetes reported by the Japanese Ministry of Health and Welfare the authors found a threefold excess in extranodal non-Hodgkin's lymphoma. The risk of nodal non-Hodgkin's lymphoma was not significantly increased.

    We evaluated this association in data from two case-control …

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