Objective: To assess correlation between type
of
breast cyst and risk of breast cancer in women with gross cystic
disease of the breast.
Design: Cohort study of women with breast cysts
aspirated between 1983 and 1993 who were followed up until December
1994 for occurrence of breast cancer.
Setting: Major cancer prevention centre.
Subjects: 802 women with aspirated breast cysts.
Main outcome measures: Type of breast cyst based on
cationic content of cyst fluid: type I (potassium:sodium ratio g1.5),
type II (potassium:sodium ratio <1.5), or mixed (both types).
Subsequent occurrence and type of breast cancer.
Results: After median follow up of six years (range
2-12 years) 15 cases of invasive breast cancer and two ductal
carcinomas in situ were diagnosed in the cohort: 12 invasive cancers
(and two carcinomas in situ) among the 417 women with type I cysts, two
cancers among the 325 women with type II cysts, and one among the 60
women with mixed cysts. The incidence of breast cancer in women with
type I cysts was significantly higher than that in women with type II
cysts (relative risk 4.62 (95% confidence interval 1.26 to 29.7)).
These results were confirmed after adjustment for several risk factors
for breast cancer (relative risk 4.24 (1.12 to 27.5)).
Conclusions: The increased risk of breast cancer of
women with breast cysts seems to be concentrated among women with type
I breast cysts.
Unit of
Clinical Epidemiology and Trials,
National Institute for Cancer
Research,
Largo Rosanna Benzi 10,
16132 Genova,
Italy
Paolo
Bruzzi, head
Massimo Costantini,
epidemiologist
Department of Clinical and
Biological Sciences,
Medical Oncology,
University of Turin at St Luigi
Hospital,
10043 Orbassano (Torino),
Italy
Luigi Dogliotti,
professor of oncology
Mirella Torta,
research assistant
Cancer
Prevention Center,
St. Maria delle Croci Hospital,
Via Missiroli 10,
48100 Ravenna,
Italy
Carlo Naldoni, deputy
head
Lauro Bucchi,
epidemiologist
Alessandra Cicognani,
research fellow
Gian Franco Buzzi,
director
Department of Clinical and Biological
Sciences,
Internal Medicine,
University of Turin at St. Luigi Hospital,
10043 Orbassano (Torino),
Italy
Alberto Angeli,
professor of internal
medicine
Correspondence to: Dr
Bruzzi.