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BMJ No 7085 Volume 314

Abstracts Saturday 29 March 1997


Cohort study of association of risk of breast cancer with cyst type in women with gross cystic disease of the breast

Paolo Bruzzi, Luigi Dogliotti, Carlo Naldoni, Lauro Bucchi, Massimo Costantini, Alessandra Cicognani, Mirella Torta, Gian Franco Buzzi, Alberto Angeli

Abstract

Objective: To assess correlation between type of breast cyst and risk of breast cancer in women with gross cystic disease of the breast.

Design: Cohort study of women with breast cysts aspirated between 1983 and 1993 who were followed up until December 1994 for occurrence of breast cancer.

Setting: Major cancer prevention centre.

Subjects: 802 women with aspirated breast cysts.

Main outcome measures: Type of breast cyst based on cationic content of cyst fluid: type I (potassium:sodium ratio g1.5), type II (potassium:sodium ratio <1.5), or mixed (both types). Subsequent occurrence and type of breast cancer.

Results: After median follow up of six years (range 2-12 years) 15 cases of invasive breast cancer and two ductal carcinomas in situ were diagnosed in the cohort: 12 invasive cancers (and two carcinomas in situ) among the 417 women with type I cysts, two cancers among the 325 women with type II cysts, and one among the 60 women with mixed cysts. The incidence of breast cancer in women with type I cysts was significantly higher than that in women with type II cysts (relative risk 4.62 (95% confidence interval 1.26 to 29.7)). These results were confirmed after adjustment for several risk factors for breast cancer (relative risk 4.24 (1.12 to 27.5)).

Conclusions: The increased risk of breast cancer of women with breast cysts seems to be concentrated among women with type I breast cysts.

Unit of Clinical Epidemiology and Trials,
National Institute for Cancer Research,
Largo Rosanna Benzi 10,
16132 Genova,
Italy
Paolo Bruzzi, head
Massimo Costantini, epidemiologist

Department of Clinical and Biological Sciences,
Medical Oncology,
University of Turin at St Luigi Hospital,
10043 Orbassano (Torino),
Italy
Luigi Dogliotti, professor of oncology
Mirella Torta, research assistant

Cancer Prevention Center,
St. Maria delle Croci Hospital,
Via Missiroli 10,
48100 Ravenna,
Italy
Carlo Naldoni, deputy head
Lauro Bucchi, epidemiologist
Alessandra Cicognani, research fellow
Gian Franco Buzzi, director

Department of Clinical and Biological Sciences,
Internal Medicine,
University of Turin at St. Luigi Hospital,
10043 Orbassano (Torino),
Italy
Alberto Angeli, professor of internal medicine

Correspondence to: Dr Bruzzi.

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Retirement on grounds of ill health: cross sectional survey in six organisations in United Kingdom

C J M Poole

Abstract

Objective: To assess the process and outcome of retirement due to ill health in six large organisations.

Design: Cross sectional study of the rate of retirement due to ill health by age, sex, and length of service. Principal diagnoses by age and length of service were also compared.

Setting: Four public and two private large employers in the United Kingdom.

Main outcome measures: Rates of retirement on the grounds of ill health by age, sex, and length of service of employees contributing to pension schemes.

Results: Rates of ill health retirement varied from 20 to 250 per 10,000 contributing members, and in two organisations the rate varied geographically within the same organisation. In the two organisations that provided data by sex, women retired at a greater rate than men under age 40 and over age 50. In four organisations the modal age or length of service coincided with enhancements in benefits. In the four that provided information on diagnoses, musculoskeletal and minor psychiatric illnesses were the most common reasons for retirement.

Conclusion: The granting of ill health retirement benefits may not be determined by illness. There is a need for some employers and pension schemes to improve their processes for granting benefits. Doctors should be wary of conflicts of interest and work to guidelines when they advise pension schemes about the merits of an application for benefits.

Dudley Priority Health NHS Trust,
Central Clinic,
Dudley,
West Midlands DY2 7BX
C J M Poole, consultant occupational physician

Full text on BioMedNet


Cross sectional study of contribution of clinical assessment and simple cardiac investigations to diagnosis of left ventricular systolic dysfunction in patients admitted with acute dyspnoea

Neil D Gillespie, Graeme McNeill, Terence Pringle, Simon Ogston, Allan D Struthers, Stuart D Pringle

Abstract

Objective: To assess the comparative contribution of clinical assessment, electrocardiography, and chest radiography to the diagnosis of left ventricular systolic dysfunction in patients admitted to a general medical ward with acute dyspnoea.

Design: Prospective cross sectional study.

Setting: Acute medical admissions ward of a teaching hospital.

Subjects: 71 randomly selected patients admitted with acute dyspnoea.

Main outcome measures: Sensitivity and specificity of each investigation and logistic regression analysis of each variable in identifying left ventricular systolic dysfunction.

Results: Clinical assessment in this cohort of patients with severe dyspnoea was generally sensitive (sensitivity 81%). Patients were divided into three groups on the basis of clinical assessment. In the first group (37 patients) the diagnosis of systolic dysfunction was clear, in the second (22) it was in doubt, and in the third (12) it was unlikely. The sensitivity of clinical assessment in identifying left ventricular systolic dysfunction was 81% and the specificity was 47%. The specificity of diagnosis was improved by electrocardiography (69%) and chest radiography (92%). Logistic regression analysis showed that isolated pulmonary crepitations were a comparatively poor predictor of left ventricular systolic dysfunction (chi-2 =10.215, P=0.0014) but that a full clinical examination had reasonable predictive value (chi-2 =24.82, P<0.00001). The combination of clinical assessment and chest radiography improved the accuracy of diagnosis (chi-2 =28.08, P<0.00001), as did the combination of clinical assessment and electrocardiography (chi-2 =32.41, P<0.00001).

Conclusion: Clinical assessment in patients admitted with acute dyspnoea is comparatively accurate. Patients with abnormal results on chest radiography, electrocardiography, and clinical examination have a high likelihood of having left ventricular systolic dysfunction. Echocardiography contributes little more to the diagnosis in these patients and may be more efficiently directed towards patients in whom the diagnosis is still in doubt after clinical assessment, chest radiography, and electrocardiography.

Correspondence to: Dr N D Gillespie,
Department of Medicine (Section of Ageing and Health),
Ninewells Hospital and Medical School,
Dundee DD1 9SY.

Departments of Cardiology,
Clinical Pharmacology, and Epidemiology,
Ninewells Hospital,
Dundee DD1 9SY
Neil D Gillespie, research fellow, department of cardiology
Graeme McNeill, consultant cardiologist
Terence Pringle, consultant cardiologist
Simon Ogston, statistician, department of epidemiology
Allan D Struthers, professor of clinical pharmacology
Stuart D Pringle, consultant cardiologist

Full text on BioMedNet


Interpractice audit of diagnosis and management of hypertension in primary care: educational intervention and review of medical records

Mahendra Mashru, Ariel Lant

Abstract

Objective: To determine whether peer review medical audit in a primary care setting changes clinical behaviour in relation to the management of hypertension.

Design: Review of medical records in general practices to identify hypertensive patients followed up by assessment of the pre-educational and post-educational management of interventions.

Setting: Six general practices in north west London picked at random within defined criteria of geography and size.

Subjects: 740 hypertensive patients managed by 25 different general practitioners.

Main outcome measures: Improved level of care in terms of better diagnosis by having at least three blood pressure readings before the start of drug treatment, better level of recordings of lifestyle parameters as shown by the level of recordings of body mass index and total lipid values, and better control of blood pressure and harm minimisation as shown by the level of recordings of urea and electrolyte values.

Results: Improvement was noted in the level of recordings of body mass index, total lipid concentrations, and urea and electrolyte values but not in better diagnosis or blood pressure control.

Conclusion: Clinical behaviour of general practitioners can be changed by peer review but more complex behavioural changes which require the cooperation of the patients and cognitive actions by the general practitioners need further investigation.

Department of Clinical Pharmacology and Therapeutics,
Charing Cross and Westminster Medical School,
Chelsea and Westminster Hospital,
London SW10 9NH
Mahendra Mashru, North Thames clinical research fellow in general practice
Ariel Lant, professor

Correspondence to: Dr Mahendra Mashru,
19 King Edward's Road,
Ruislip,
Middlesex HA4 7AG.

Full text on BioMedNet
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